The effect of different anesthetics on neurovascular coupling.
The effect of different anesthetics on neurovascular coupling.
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DOI：
10.1016/j.neuroimage.2010.03.060
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发表时间：
2010-07-15
期刊：
影响因子：
5.7
通讯作者：
Boas, David A.
中科院分区：
文献类型：
--
作者：
Franceschini, Maria Angela;Radhakrishnan, Harsha;Thakur, Kiran;Wu, Weicheng;Ruvinskaya, Svetlana;Carp, Stefan A.;Boas, David A.
迄今为止，大多数神经血管耦合的研究集中在丘脑传入的活动在第四层和相应的大尖峰活动的功能性充血负责。本文重点介绍了继发性和晚期皮质-皮质传递在神经血管耦合中的作用。33只雄性Sprague-Dawley大鼠根据维持麻醉剂-α-氯醛糖、戊巴比妥、氯胺酮-甲苯噻嗪、芬太尼-氟哌利多、异氟烷或丙泊酚分为6组，在事件相关前爪电刺激的多种条件下同时进行头皮脑电图（EEG）和弥散光学成像（DOI）测量。将体感诱发电位（SEP）分解为四个分量，并研究了哪一个分量最能预测血流动力学反应的问题。线性回归分析的结果表明，血流动力学反应是最好的相关性与继发性和晚期皮质-皮质传输，而不是在第四层的初始丘脑输入活动。基线脑血流量（CBF）与神经活动相互作用并影响诱发的血流动力学反应。最后，神经血管耦合似乎在所有使用的麻醉剂中是相同的。
To date, the majority of neurovascular coupling studies focused on the thalamic afferents' activity in layer IV and the corresponding large spiking activity as responsible for functional hyperemia. This paper highlights the role of the secondary and late cortico-cortical transmission in neurovascular coupling. Simultaneous scalp electroencephalography (EEG) and diffuse optical imaging (DOI) measurements were obtained during multiple conditions of event-related electrical forepaw stimulation in 33 male Sprague-Dawley rats divided into 6 groups depending on the maintaining anesthetic - alpha-chloralose, pentobarbital, ketamine-xylazine, fentanyl-droperidol, isoflurane, or propofol. The somatosensory evoked potentials (SEP) were decomposed into four components and the question of which best predicts the hemodynamic responses was investigated. Results of the linear regression analysis show that the hemodynamic response is best correlated with the secondary and late cortico-cortical transmissions and not with the initial thalamic input activity in layer IV. Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used.
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影响因子：
3
作者：
Chen, Yu;Aguirre, Aaron D.;Ruvinskaya, Lana;Devor, Anna;Boas, David A.;Fujimoto, James G.
通讯作者：
Fujimoto, James G.
DOI：
10.1097/00004647-200405000-00005
发表时间：
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影响因子：
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