An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.
An integrated overview of spatiotemporal organization and regulation in mitosis in terms of the proteins in the functional supercomplexes.
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根据功能超复合物中的蛋白质对有丝分裂的时空组织和调节进行综合概述
DOI：
10.3389/fmicb.2014.00573
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发表时间：
2014
影响因子：
5.2
通讯作者：
Ren J
中科院分区：
文献类型：
--
作者：
Zheng Y;Guo J;Li X;Xie Y;Hou M;Fu X;Dai S;Diao R;Miao Y;Ren J
真核细胞可以通过细胞分裂/有丝分裂这一关键的细胞过程进行分裂，从而产生两个具有相同遗传信息的子细胞。大量的专用蛋白参与这一过程，并在时空上组装成3种不同的超复杂结构/细胞器，包括着丝体/纺锤极体、着丝点/着丝粒和分裂沟/中间体/芽颈，从而有序地精确调节染色体排列、染色体分离和细胞质分裂等细胞分裂/有丝分裂事件。近年来，人们对这些亚细胞细胞器的蛋白质组成和结构进行了许多研究，旨在揭示细胞器组装途径，确定细胞器功能的分子机制，从而为多种疾病的治疗提供新的策略。然而，细胞器是高度动态的结构，很难识别整个组成部分。在这里，我们回顾了目前已知的控制细胞器组织和功能的蛋白质成分，特别是在人类和酵母细胞中，并讨论了在细胞分裂过程中介导细胞器之间通信的多定位蛋白质成分。
Eukaryotic cells may divide via the critical cellular process of cell division/mitosis, resulting in two daughter cells with the same genetic information. A large number of dedicated proteins are involved in this process and spatiotemporally assembled into three distinct super-complex structures/organelles, including the centrosome/spindle pole body, kinetochore/centromere and cleavage furrow/midbody/bud neck, so as to precisely modulate the cell division/mitosis events of chromosome alignment, chromosome segregation and cytokinesis in an orderly fashion. In recent years, many efforts have been made to identify the protein components and architecture of these subcellular organelles, aiming to uncover the organelle assembly pathways, determine the molecular mechanisms underlying the organelle functions, and thereby provide new therapeutic strategies for a variety of diseases. However, the organelles are highly dynamic structures, making it difficult to identify the entire components. Here, we review the current knowledge of the identified protein components governing the organization and functioning of organelles, especially in human and yeast cells, and discuss the multi-localized protein components mediating the communication between organelles during cell division.
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DOI：
10.1083/jcb.105.5.2053
发表时间：
1987-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cooke CA;Heck MM;Earnshaw WC
通讯作者：
Earnshaw WC
DOI：
10.1083/jcb.153.4.865
发表时间：
2001-05-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Adams RR;Maiato H;Earnshaw WC;Carmena M
通讯作者：
Carmena M
影响因子：
56.9
作者：
Daniels, MJ;Wang, YM;Venkitaraman, AR
通讯作者：
Venkitaraman, AR
影响因子：
21.3
作者：
Fodde, R;Kuipers, J;Clevers, H
通讯作者：
Clevers, H
DOI：
10.1083/jcb.149.1.125
发表时间：
2000-04-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bloecher A;Tatchell K
通讯作者：
Tatchell K