Differential correlation between interleukin patterns in disseminated and chronic human paracoccidioidomycosis
Differential correlation between interleukin patterns in disseminated and chronic human paracoccidioidomycosis
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播散性和慢性人类副球孢子菌病中白细胞介素模式的差异相关性
DOI：
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发表时间：
1995
影响因子：
4.6
通讯作者：
N. Foss
中科院分区：
文献类型：
--
作者：
C. L. Silva;M. F. Silva;L. Faccioli;R. C. Pietro;S. Cortez;N. Foss
为了更好地了解副球囊霉菌病(PCM)的免疫调节紊乱，对该病两极分化的临床表现中白细胞介素型、淋巴细胞增殖、C反应蛋白(CRP)和特异性抗体水平之间的可能相关性进行了研究。我们研究了16名PCM患者，其中8名患有播散性疾病(4名正在治疗，4名未治疗)，8名患有慢性病。与慢性病患者相比，播散性疾病患者表现出较高的巴氏副球虫抗原抗体效价。未经治疗的播散型PCM患者血清肿瘤坏死因子(TNF)、IL-1、IL-6和CRP水平升高，与患者外周血单个核细胞(PBMC)对植物血凝素(PHA)的低促分裂反应(P<；0·01)和高抗体滴度(P<；0·001)呈正相关。播散型PCM患者IL-1与IL-6呈正相关(P=0·0007)，IL-1与肿瘤坏死因子呈正相关(P=0·0045)，IL-1与IL-6与高抗体滴度呈正相关(P=0·0834，P=0·0631)，IL-1、IL-6、肿瘤坏死因子与CRP呈正相关。相比之下，在接受治疗的播散性和慢性患者或对照组中，未发现与白介素类的相关性。未治疗的播散型PCM患者IL-4水平与抗体产生呈负相关(r=−0·4770)，而慢性PCM患者IL-4水平与抗真菌抗体滴度呈显著正相关(P=0·0820)。慢性PCM患者IL-2水平与抗体产生呈负相关(r=−0.6313，P=0.0628)。IL-2与IL-6水平呈负相关(P=0.0501)，IL-2与IL-4呈负相关(P=0.0131)。炎性细胞因子可能在PCM的某些方面起关键作用，如肉芽肿反应、高丙种球蛋白血症、T细胞免疫抑制等。
In an attempt to understand better the immunoregulatory disorders in paracoccidioidomycosis (PCM), the possible correlation between interleukin pattern, lymphoproliferation, C‐reactive protein (CRP) and specific antibody levels was investigated in the polarized clinical forms of this disease. We studied 16 PCM patients, eight with the disseminated disease (four under treatment and four non‐treated) and eight with the chronic disease. The patients with disseminated disease exhibited high antibody titres specific to Paracoccididoides brasiliensis antigen compared with patients with the chronic form of disease. Tumour necrosis factor (TNF), IL‐1, IL‐6 and CRP in the serum of non‐treated disseminated PCM patients were increased, which correlated positively with the low mitogenic response of peripheral blood mononuclear cells (PBMC) to phytohaemagglutinin (PHA) (P < 0·01) and with the high antibody titres (P < 0·001) of these patients. Moreover, we found in the disseminated PCM patients positive correlations between IL‐1 and IL‐6 (P = 0·0007); IL‐1 and TNF (P = 0·0045); IL‐1 and IL‐6 with the high antibody titres (P = 0·0834 and P = 0·0631, respectively); IL‐1, IL‐6 and TNF with CRP levels. By contrast, no correlations were found with those interleukins in the treated disseminated and chronic patients or in controls. It was interesting to find an inverse correlation between IL‐4 and antibody production in non‐treated disseminated PCM (r = −0·4770); moreover, a significant correlation (P = 0·0820) was found in chronic PCM patients with respect to the low level of either IL‐4 and antibody titres against fungus antigen. Chronic PCM patients also had IL‐2 levels inversely correlated with antibody production (r = −0·6313; P = 0·0628). Inverse correlations were also observed between IL‐2 and IL‐6 levels in non‐treated disseminated patients (P = 0·0501) and between IL‐2 and IL‐4 in chronic patients (P = 0·0131). The inflammatory cytokines might have a pivotal role in the genesis and in control of some aspects of the disease, such as granulomatous reaction, hypergammaglobulinaemia and depression of T cell‐mediated immunity in PCM.
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人 C 反应蛋白与小鼠巨噬细胞的结合是由不同的受体介导的。
DOI：
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发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Zahedi,K;Tebo,JM;Siripont,J;Klimo,GF;Mortensen,RF
通讯作者：
Mortensen,RF
DOI：
10.1073/pnas.88.10.4538
发表时间：
1991-05-01
影响因子：
11.1
作者：
PARRONCHI, P;MACCHIA, D;ROMAGNANI, S
通讯作者：
ROMAGNANI, S
定义对病原体的保护性反应：麻风病灶中的细胞因子谱。
DOI：
10.1126/science.254.5029.277
发表时间：
1991
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Yamamura,M;Uyemura,K;Deans,RJ;Weinberg,K;Rea,TH;Bloom,BR;Modlin,RL
通讯作者：
Modlin,RL
DOI：
10.1073/pnas.82.24.8667
发表时间：
1985-12-01
影响因子：
11.1
作者：
GAMBLE, JR;HARLAN, JM;VADAS, MA
通讯作者：
VADAS, MA
影响因子：
4.4
作者：
S. Klebanoff;M. Vadas;J. Harlan;L. Sparks;J. Gamble;J. Agosti;A. Waltersdorph
通讯作者：
S. Klebanoff;M. Vadas;J. Harlan;L. Sparks;J. Gamble;J. Agosti;A. Waltersdorph