Androgens and bone.
Androgens and bone.
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DOI：
10.1016/j.steroids.2008.10.003
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发表时间：
2009-03
期刊：
影响因子：
2.7
通讯作者：
Khosla, Sundeep
中科院分区：
文献类型：
--
作者：
Clarke, Bart L.;Khosla, Sundeep
睾酮是男性睾丸产生的主要性腺性类固醇。女性的卵巢也会产生少量的睾酮。肾上腺产生较弱的雄激素脱氢表雄酮、硫酸脱氢表雄酮和雄烯二酮。这些雄激素共同影响男性和女性一生中的骨骼稳态，特别是在青春期和成年期。由于睾酮可以通过芳香化酶代谢为雌二醇，因此对于哪种性腺性类固醇具有更大的骨骼效应一直存在争议。目前的证据表明，雌二醇在维持骨骼健康方面比睾酮发挥更大的作用，但雄激素也对骨骼有直接的有益作用。超生理水平的睾酮可能通过与雄激素受体的直接相互作用以及芳构化为雌二醇后由雌激素受体介导的作用对骨产生与较低水平相似的影响。事实上，由于内源性睾酮（和雌激素）水平的抑制，高剂量的合成的非芳香化雄激素是否可能对骨骼有害，这是一个值得进一步研究的潜在问题。
Testosterone is the major gonadal sex steroid produced by the testes in men. Testosterone is also produced in smaller amounts by the ovaries in women. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These androgens collectively affect skeletal homeostasis throughout life in both men and women, particularly at puberty and during adult life. Because testosterone can be metabolized to estradiol by the aromatase enzyme, there has been controversy as to which gonadal sex steroid has the greater skeletal effect. The current evidence suggests that estradiol plays a greater role in maintenance of skeletal health than testosterone, but that androgens also have direct beneficial effects on bone. Supraphysiological levels of testosterone likely have similar effects on bone as lower levels via direct interaction with androgen receptors, as well as effects mediated by estrogen receptors after aromatization to estradiol. Whether high doses of synthetic, non-aromatizable androgens may, in fact, be detrimental to bone due to suppression of endogenous testosterone (and estrogen) levels is a potential concern that warrants further study.
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影响因子：
5.8
作者：
BUCHANAN, JR;HOSPODAR, P;DEMERS, LM
通讯作者：
DEMERS, LM
影响因子：
5.8
作者：
Barrett-Connor, E;Mueller, JE;Sartoris, DJ
通讯作者：
Sartoris, DJ
影响因子：
5.8
作者：
Abu, EO;Horner, A;Compston, JE
通讯作者：
Compston, JE
影响因子：
5.8
作者：
Bertelloni, S;Baroncelli, GI;Saggese, G
通讯作者：
Saggese, G
DOI：
10.1073/pnas.97.8.4279
发表时间：
2000-04-11
影响因子：
11.1
作者：
Baulieu, EE;Thomas, G;Forette, F
通讯作者：
Forette, F