Association between Haloperidol use and Risk of Rheumatoid Arthritis.
Association between Haloperidol use and Risk of Rheumatoid Arthritis.
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氟哌啶醇使用与类风湿关节炎风险之间的关联。
DOI：
10.1101/2023.09.11.23295367
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Magagnoli,Joseph
中科院分区：
文献类型：
--
作者：
Ambati,VidyaL;Cummings,TammyH;Yerramothu,Praveen;Nguyen,Joseph;Sutton,SScott;Werner,BrianC;Magagnoli,Joseph
尊敬的编辑：一项非对照病例系列报告了氟哌啶醇在类风湿性关节炎（RA）中的获益。1 FDA不良事件报告系统的一项研究报告称，在RA患者中，抗精神病药物（包括氟哌啶醇）的使用者较少，并得出结论，抗精神病药物可以降低患RA的风险。2然而，这些结果只表明了匡威的情况：RA与抗精神病药物使用风险降低有关;它们并不表明抗精神病药物降低了RA的风险。同一项研究还检查了日本的一个小型员工保险数据库，并报告了RA和抗精神病药物（包括氟哌啶醇）之间的逆时间关系。这两项研究的局限性包括样本量小、未经验证和记录不完整、缺乏对社会人口统计学或临床混杂因素的纠正、处方时间趋势的变化以及选择性失访。因此，我们试图进行一项稳健的药物流行病学研究，以确定FDA批准的治疗精神分裂症或抽动秽语障碍的药物氟哌啶醇是否会影响三个大型全国性健康保险数据库（包括大部分美国人口）中RA事件的风险。我们这样做的目的是确定一种已经在临床使用的廉价药物是否可以重新用于RA，这种疾病影响着全球数千万人。我们研究了三个健康保险数据库：PearlDiver Mariner（2010-2021），IBM Marketscan Research Databases（2006-2020）和退伍军人管理局（VA）健康数据库（2001-2021）（支持信息：表S1-S4）。入选标准为至少6个月随访，至少18岁，在两个不同的场合诊断出精神分裂症或抽动秽语障碍，并接受抗精神病药物治疗。排除诊断为精神分裂症或抽动秽语障碍前的RA（支持性信息：图S1）。疾病索赔由ICD-9-CM和ICD-10-CM代码识别。药物暴露量由仿制药或品牌版本的处方确定。从首次开抗精神病药到诊断为RA的时间是因变量。敏感性分析使用精神分裂症或抽动秽语障碍的诊断作为索引日期，并在60天内标记抗精神病药物治疗。
Dear Editors, An uncontrolled case‐series reported a benefit of haloperidol in rheumatoid arthritis (RA). 1 A study of the FDA Adverse Events Reporting System reported that among RA patients there were fewer users of antipsychotic drugs, including haloperidol, and concluded that antipsychotic drugs could reduce the risk of developing RA. 2 However, these results only suggest the converse: that RA is associated with a reduced risk of antipsychotic use; they do not indicate that antipsychotics reduce the risk of RA. The same study also examined a small employee insurance database in Japan and reported an inverse temporal relationship between RA and antipsychotic drugs, including haloperidol. Limitations of these two studies include small size, unverified and incomplete records, lack of correction for sociodemographic or clinical confounders, changing time‐trends in prescriptions, and selective loss to follow‐up. Therefore, we sought to undertake a robust pharmacoepidemiologic study of whether haloperidol, an FDA‐approved drug for the treatment of schizophrenia or Tourette disorder, affects the risk of incident RA in three large nationwide health insurance databases that comprise most of the United States population. We did so with the goal of determining whether an inexpensive drug already in clinical use could be repurposed for RA, a disease that affects tens of millions of people worldwide. We studied three health insurance databases: PearlDiver Mariner (2010–2021), IBM Marketscan Research Databases (2006–2020), and Veterans Administration (VA) Health database (2001–2021)(Supporting Information: Tables S1–S4). Inclusion criteria were at least 6 months follow‐up, at least 18 years of age, schizophrenia or Tourette disorder diagnosed on two separate occasions, and treatment with antipsychotics. RA before diagnosis of schizophrenia or Tourette disorder was exclusionary (Supporting Information: Figure S1). Disease claims were identified by ICD‐9‐CM and ICD‐10‐CM codes. Drug exposure was determined by prescriptions for generic or brand versions. Time from first prescription of antipsychotics to diagnosis of RA was the dependent variable. Sensitivity analyses were performed using diagnosis of schizophrenia or Tourette disorder as the index date and flagging treatment with antipsychotics within 60 days of
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聚乙二醇附着的抗氧化酶可降低大鼠的肺氧毒性。
DOI：
10.1152/jappl.1989.66.2.584
发表时间：
1989
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
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1981
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
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DOI：
10.1016/0167-4889(83)90004-6
发表时间：
1983
期刊：
Biochimica et biophysica acta
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通讯作者：
Shapiro,DL
通过静脉注射脂质体包埋的过氧化氢酶和超氧化物歧化酶来防止氧中毒。
影响因子：
15.9
作者：
J. Turrens;J. Crapo;B. Freeman
通讯作者：
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DOI：
10.1152/jappl.1990.69.6.2078
发表时间：
1990
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
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Matalon,S