Computerized planning of prostate cryosurgery using variable cryoprobe insertion depth.

Computerized planning of prostate cryosurgery using variable cryoprobe insertion depth.
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DOI:
10.1016/j.cryobiol.2008.11.008
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发表时间:
2010-02
期刊:
影响因子:
2.7
通讯作者:
Rabin, Yoed
Rabin, Yoed
中科院分区:
生物学3区
文献类型:
--
作者:
Rossi, Michael R.;Tanaka, Daigo;Shimada, Kenji;Rabin, Yoed

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目前的研究提出了一种计算机化的前列腺冷冻手术计划,使用可变的插入深度策略。这项研究是一个正在进行的努力,以开发计算机化的工具,冷冻手术的一部分。基于典型的临床实践,先前的自动规划方案要求所有冷冻探针在单个插入深度处对准。目前的研究调查了去除这一限制的好处,与基于统一插入深度计划以及所谓的“回撤程序”的结果进行了比较。规划是基于所谓的“气泡填充法”,其质量与生物传热模拟评估。本研究基于五个3D前列腺模型,通过超声成像重建,冷冻探头有效长度范围为15 mm至35 mm。与其他放置方法相比,可变插入深度技术可始终提供上级结果。此外,它表明,最佳的有效长度和冷冻探针的最佳数量不同的前列腺模型,根据目标区域的大小和形状。由于其计算成本低,新的计划可以用来确定最佳的冷冻探针布局为一个给定的前列腺模型在真实的时间。
The current study presents a computerized planning scheme for prostate cryosurgery using a variable insertion-depth strategy. This study is a part of an ongoing effort to develop computerized tools for cryosurgery. Based on typical clinical practices, previous automated planning schemes have required that all cryoprobes be aligned at a single insertion depth. The current study investigates the benefit of removing this constraint, in comparison with results based on uniform insertion-depth planning as well as the so-called “pullback procedure”. Planning is based on the so-called “bubble-packing method”, and its quality is evaluated with bioheat transfer simulations. This study is based on five 3D prostate models, reconstructed from ultrasound imaging, and cryoprobe active length in the range of 15 mm to 35 mm. The variable insertion depth technique is found to consistently provide superior results when compared to the other placement methods. Furthermore, it is shown that both the optimal active length and the optimal number of cryoprobes vary among prostate models, based on the size and shape of the target region. Due to its low computational cost, the new scheme can be used to determine the optimal cryoprobe layout for a given prostate model in real time.
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