Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.
Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy.
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增生性糖尿病性视网膜病患者的玻璃体幽默中的类果酸轮廓。
DOI：
10.3390/ijms21207451
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发表时间：
2020-10-09
影响因子：
5.6
通讯作者：
Iyer SSR
中科院分区：
文献类型：
--
作者：
Lin AL;Roman RJ;Regan KA;Bolch CA;Chen CJ;Iyer SSR
糖尿病视网膜病变是一种潜在的致盲后遗症，涉及促血管生成和炎症途径的复杂相互作用。在这项研究中，我们比较了人类玻璃体液中促血管生成的花生四烯酸衍生介质的水平，这些介质是从患有高危增生性糖尿病视网膜病变的眼睛与对照组中获得的。结果表明，脂氧合酶和细胞色素P450衍生的类二十烷酸（5-HETE，12-HETE，20-HETE和20-COOH-AA）升高，并且在牵引性视网膜脱离的眼睛中测量的水平与没有牵引性视网膜脱离的眼睛相比似乎没有差异。这些结果提供了进一步了解这种疾病的发病机制，并为未来潜在的治疗药物，目标花生四烯酸代谢物治疗糖尿病视网膜病变的发展。
Proliferative diabetic retinopathy is a potentially blinding sequela of uncontrolled diabetes that involves a complex interaction of pro-angiogenic and inflammatory pathways. In this study, we compared the levels of pro-angiogenic arachidonic acid-derived mediators in human vitreous humor obtained from eyes with high-risk proliferative diabetic retinopathy versus controls. The results indicated that lipoxygenase and cytochrome P450-derived eicosanoids were elevated (5-HETE, 12-HETE, 20-HETE, and 20-COOH-AA), and there appeared to be no differences in levels measured in eyes with tractional retinal detachments versus those without. These results provide further insight into the pathogenesis of this disease and for the development of future potential therapeutic agents that target arachidonic acid metabolites to treat diabetic retinopathy.
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影响因子：
4.1
作者：
Augustin, AJ;Grus, FH;Spitznas, M
通讯作者：
Spitznas, M
影响因子：
6.5
作者：
Ibrahim, Ahmed S.;Elshafey, Sally;Al-Shabrawey, Mohamed
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Al-Shabrawey, Mohamed
影响因子：
13.7
作者：
Martidis, A;Duker, JS;Baumal, C
通讯作者：
Baumal, C
影响因子：
7.7
作者：
Gubitosi-Klug, Rose A.;Talahalli, Ramaprasad;Kern, Timothy S.
通讯作者：
Kern, Timothy S.
影响因子：
4.2
作者：
ADAMIS, AP;MILLER, JW;YEO, KT
通讯作者：
YEO, KT