Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway
Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway
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SNK-SPAR通路介导微波辐射导致海马神经元树突棘收缩
DOI：
10.1016/j.brainres.2017.11.020
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发表时间：
2018-01
期刊：
影响因子：
2.9
通讯作者：
Hu Xiang Jun
中科院分区：
文献类型：
--
作者：
Zhi Wei Jia;Peng Rui Yun;Li Hai Juan;Zou Yong;Yao Bin Wei;Wang Chang Zhen;Liu Zong Huan;Gao Xiao Hui;Xu Xin Ping;Dong Ji;Zhao Li;Zhou Hong Mei;Wang Li Feng;Hu Xiang Jun
微波的普及引起了人们对其健康影响的关注，包括与树突棘可塑性密切相关的认知功能。SNK-SPAR是神经元在慢性活动升高期间的稳态可塑性的分子途径。本研究采用微波辐射（30 mW/cm ~ 2，6 min，3次/周，共6周）对Wistar大鼠进行辐射。观察微波照射后不同时间点大鼠的空间学习记忆功能、海马神经元及其树突棘的分布、超微结构以及SNK-SPAR通路相关关键分子的变化。大鼠空间学习记忆能力下降，颗粒细胞棘丢失，锥体细胞成熟棘皱缩，海马神经元超微结构改变。30 mW/cm 2微波辐射后，SNK表达上调，导致SPAR和PSD-95表达降低，推测是上述变化的原因。结论：微波辐射通过SNK-SPAR通路导致海马树突棘萎缩甚至缺失，导致认知功能障碍。
The popularization of microwave raised concerns about its influence on health including cognitive function which is associated greatly with dendritic spines plasticity. SNK-SPAR is a molecular pathway for neuronal homeostatic plasticity during chronically elevated activity. In this study, Wistar rats were exposed to microwaves (30 mW/cm2for 6 min, 3 times/week for 6 weeks). Spatial learning and memory function, distribution of dendritic spines, ultrastructure of the neurons and their dendritic spines in hippocampus as well as the related critical molecules of SNK-SPAR pathway were examined at different time points after microwave exposure. There was deficiency in spatial learning and memory in rats, loss of spines in granule cells and shrinkage of mature spines in pyramidal cells, accompanied with alteration of ultrastructure of hippocampus neurons. After exposure to 30 mW/cm2microwave radiation, the up-regulated SNK induced decrease of SPAR and PSD-95, which was thought to cause the changes mentioned above. In conclusion, the microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments.
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影响因子：
3.1
作者：
Paulin JJ;Haslehurst P;Fellows AD;Liu W;Jackson JD;Joel Z;Cummings DM;Edwards FA
通讯作者：
Edwards FA
影响因子：
3.5
作者：
Bourne, Jennifer N.;Harris, Kristen M.
通讯作者：
Harris, Kristen M.
DOI：
10.1016/j.ijdevneu.2013.06.011
发表时间：
2013-11-01
影响因子：
1.8
作者：
Chutabhakdikul, Naunchan;Surakul, Pornprom
通讯作者：
Surakul, Pornprom
影响因子：
2.6
作者：
V. Vorobyov;B. Janać;V. Pešić;Z. Prolić
通讯作者：
V. Vorobyov;B. Janać;V. Pešić;Z. Prolić
微波暴露通过过度激活 NMDA 受体信号通路损害大鼠海马和 PC12 细胞的突触可塑性
影响因子：
3.5
作者：
Xiong Lu;Sun Cheng Feng;Peng Rui Yun
通讯作者：
Peng Rui Yun