A parallel adaptive finite element simplified spherical harmonics approximation solver for frequency domain fluorescence molecular imaging.
A parallel adaptive finite element simplified spherical harmonics approximation solver for frequency domain fluorescence molecular imaging.
复制标题
用于频域荧光分子成像的并行自适应有限元简化球谐函数近似求解器。
DOI：
10.1088/0031-9155/55/16/002
复制
发表时间：
2010-08-21
影响因子：
3.5
通讯作者：
Sevick-Muraca EM
中科院分区：
文献类型：
--
作者：
Lu Y;Zhu B;Shen H;Rasmussen JC;Wang G;Sevick-Muraca EM
荧光分子成像/断层扫描可能在临床前研究和临床诊断中发挥重要的未来作用。时域和频域荧光成像比连续波（CW）成像能够获得更多的测量信息，提高了荧光分子断层成像的图像质量。虽然扩散近似（DA）理论已被广泛应用于光学分子成像，但高阶光子迁移模型仍需进一步研究以匹配核成像提供的定量。本文提出了一种基于简化球谐函数（SPN）的频域并行自适应有限元求解器。为了充分评估SPN近似的性能，一个快速的时间分辨四面体为基础的Monte Carlo荧光模拟器，适用于复杂的非均匀几何形状的开发使用卷积策略，以实现模拟的荧光激发和发射。验证结果表明，高阶SPN能有效地校正扩散方程的建模误差，尤其是当组织具有高吸收特性或使用高调制频率测量时。此外，并行自适应网格演化策略提高了建模精度和仿真速度显着的真实感数字鼠标体模。该求解器是一个很有前途的平台，荧光分子层析成像使用高阶近似的辐射传输方程。
Fluorescence molecular imaging/tomography may play an important future role in preclinical research and clinical diagnostics. Time- and frequency-domain fluorescence imaging can acquire more measurement information than the continuous wave (CW) counterpart, improving the image quality of fluorescence molecular tomography. Although diffusion approximation (DA) theory has been extensively applied in optical molecular imaging, high-order photon migration models need to be further investigated to match quantitation provided by nuclear imaging. In this paper, a frequency-domain parallel adaptive finite element solver is developed with simplified spherical harmonics (SPN) approximations. To fully evaluate the performance of the SPN approximations, a fast time-resolved tetrahedron-based Monte Carlo fluorescence simulator suitable for complex heterogeneous geometries is developed using a convolution strategy to realize the simulation of the fluorescence excitation and emission. The validation results show that high-order SPN can effectively correct the modeling errors of the diffusion equation, especially when the tissues have high absorption characteristics or when high modulation frequency measurements are used. Furthermore, the parallel adaptive mesh evolution strategy improves the modeling precision and the simulation speed significantly on a realistic digital mouse phantom. This solver is a promising platform for fluorescence molecular tomography using high-order approximations to the radiative transfer equation.
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DOI：
10.1364/josaa.11.002727
发表时间：
1994-10-01
影响因子：
1.9
作者：
HASKELL, RC;SVAASAND, LO;TROMBERG, BJ
通讯作者：
TROMBERG, BJ
DOI：
10.1002/nme.1620191103
发表时间：
1983-01-01
影响因子：
2.9
作者：
KELLY, DW;GAGO, JPDR;BABUSKA, I
通讯作者：
BABUSKA, I
影响因子：
3.5
作者：
Chaudhari, AJ;Darvas, F;Leahy, RM
通讯作者：
Leahy, RM
影响因子：
3.5
作者：
Godavarty, A;Eppstein, MJ;Sevick-Muraca, EM
通讯作者：
Sevick-Muraca, EM
影响因子：
3.6
作者：
Cong, W.;Cong, A.;Wang, G.
通讯作者：
Wang, G.