Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women.
Aberrant gene expression profile in a mouse model of endometriosis mirrors that observed in women.
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DOI：
10.1016/j.fertnstert.2009.03.086
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发表时间：
2010-03-15
影响因子：
6.7
通讯作者：
Nagel SC
中科院分区：
文献类型：
--
作者：
Pelch KE;Schroder AL;Kimball PA;Sharpe-Timms KL;Davis JW;Nagel SC
To define the altered gene expression profile of endometriotic lesions in a mouse model of surgically-induced endometriosis Autologous experimental mouse model. Medical school department. Adult C57Bl6 mice. Endometriosis was surgically-induced by auto-transplantation of uterine tissue to the intestinal mesentery. Endometriotic lesions and eutopic uteri were recovered at 3 or 29 days post-induction. Altered gene expression was measured in the endometriotic lesion relative to the eutopic uterus by genome wide cDNA microarray analysis and was confirmed by real time RT-PCR for six genes. Relevant categories of altered genes were identified using gene ontology analysis to determine groups of genes enriched for altered expression. The expression of 479 and 114 genes was altered in the endometriotic lesion compared to the eutopic uterus at 3 or 29 days post-induction, respectively. Gene ontology enrichment analysis revealed that genes associated with the extracellular matrix, cell adhesions, immune function, cell growth, and angiogenesis were altered in the endometriotic lesion compared to the eutopic uterus. Based on gene expression analysis, the mouse model of surgically-induced endometriosis appears to be a good model for studying the pathophysiology and treatment of endometriosis.
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DOI：
10.1111/j.1749-6632.2002.tb02791.x
发表时间：
2002-01-01
期刊：
ENDOMETRIOSIS: EMERGING RESEARCH AND INTERVENTION STRATEGIES
影响因子：
--
作者：
Fazleabas, AT;Brudney, A;Bulun, S
通讯作者：
Bulun, S
影响因子：
6.7
作者：
Eyster, Kathleen M.;Klinkova, Olga;Hansen, Keith A.
通讯作者：
Hansen, Keith A.
影响因子：
6.7
作者：
Flores, Idhaliz;Rivera, Elizabeth;Appleyard, Caroline B.
通讯作者：
Appleyard, Caroline B.
影响因子：
3.8
作者：
Cummings, AM;Metcalf, JL;Birnbaum, L
通讯作者：
Birnbaum, L
影响因子：
6.7
作者：
Efstathiou, JA;Sampson, DA;Rupnick, MA
通讯作者：
Rupnick, MA