Engineering clinically relevant volumes of vascularized bone.
Engineering clinically relevant volumes of vascularized bone.
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DOI：
10.1111/jcmm.12569
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发表时间：
2015-05
影响因子：
5.3
通讯作者：
Brey EM
中科院分区：
文献类型：
--
作者：
Roux BM;Cheng MH;Brey EM
Vascularization remains one of the most important challenges that must be overcome for tissue engineering to be consistently implemented for reconstruction of large volume bone defects. An extensive vascular network is needed for transport of nutrients, waste and progenitor cells required for remodelling and repair. A variety of tissue engineering strategies have been investigated in an attempt to vascularize tissues, including those applying cells, soluble factor delivery strategies, novel design and optimization of bio-active materials, vascular assembly pre-implantation and surgical techniques. However, many of these strategies face substantial barriers that must be overcome prior to their ultimate translation into clinical application. In this review recent progress in engineering vascularized bone will be presented with an emphasis on clinical feasibility.
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影响因子：
4.6
作者：
Achilli TM;Meyer J;Morgan JR
通讯作者：
Morgan JR
影响因子：
5.6
作者：
Clarkin, Claire E.;Emery, Roger J.;Wheeler-Jones, Caroline P. D.
通讯作者：
Wheeler-Jones, Caroline P. D.
影响因子：
3.3
作者：
Boos, Anja M.;Loew, Johanna S.;Beier, Justus P.
通讯作者：
Beier, Justus P.
影响因子：
4.1
作者：
Correia, Cristina;Bhumiratana, Sarindr;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana
DOI：
10.1073/pnas.83.7.2114
发表时间：
1986-04-01
影响因子：
11.1
作者：
DAVIES, PF;REMUZZI, A;GIMBRONE, MA
通讯作者：
GIMBRONE, MA