Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study
Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study
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创伤后应激障碍的区域均匀性改变：静息态功能磁共振成像研究
DOI：
10.1007/s12264-012-1261-3
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发表时间：
2012-08
影响因子：
5.6
通讯作者：
Li, Lingjiang
中科院分区：
文献类型：
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作者：
Huang, Xuanyin;Shan, Baoci;Gong, Qiyong;Li, Lingjiang
目的对导致创伤后应激障碍(PTSD)易感性的大脑系统知之甚少。方法对54例创伤后应激障碍患者和72例匹配的创伤后受试者进行血氧水平依赖(BOLD)功能磁共振成像(BOLD)成像，并在静息状态下进行区域同质性(ReHo)分析。结果PTSD患者左侧顶下小叶和右额上回表现为ReHO增强，右侧颞中回和舌回表现为ReHO降低。结果PTSD患者在静息状态下表现为左侧顶下小叶和右额上回ReHO增强，右侧颞中回和舌回REHO降低。结论我们的研究结果表明，经历过大地震的创伤后应激障碍患者在静息状态下存在脑活动异常。大脑皮层局部功能连接的改变可能有助于PTSD的神经机制。
ObjectiveLittle is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention.MethodsFifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state.ResultsPTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD.ConclusionOur findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
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影响因子：
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作者：
Bremner Jd;R. Innis;C. Ng;L. Staib;R. Salomon;R. Bronen;J. Duncan;S. Southwick;J. Krystal;D. Rich;G. Zubal;H. Dey;R. Soufer;D. Charney
通讯作者：
Bremner Jd;R. Innis;C. Ng;L. Staib;R. Salomon;R. Bronen;J. Duncan;S. Southwick;J. Krystal;D. Rich;G. Zubal;H. Dey;R. Soufer;D. Charney
影响因子：
1.7
作者：
Tao Yang;Yuqi Cheng;Haijun Li;Hongyan Jiang;C. Luo;B. Shan;Lin Xu;Xiufeng Xu
通讯作者：
Tao Yang;Yuqi Cheng;Haijun Li;Hongyan Jiang;C. Luo;B. Shan;Lin Xu;Xiufeng Xu
影响因子：
1.8
作者：
Melinda D. Veltmeyer;Alexander C. McFarlane;Richard A. Bryant;T. Mayo;E. Gordon;C. Clark
通讯作者：
Melinda D. Veltmeyer;Alexander C. McFarlane;Richard A. Bryant;T. Mayo;E. Gordon;C. Clark
影响因子：
17.7
作者：
S. Southwick;C. A. Morgan;D. Charney
通讯作者：
S. Southwick;C. A. Morgan;D. Charney
DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
Tao Blockindeng
通讯作者：
Tao Blockindeng