Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.
Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.
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DOI：
10.3390/md20090576
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发表时间：
2022-09-14
期刊：
影响因子：
5.4
通讯作者：
Baker BJ
中科院分区：
文献类型：
--
作者：
Limon AD;Patabendige HMLW;Azhari A;Sun X;Kyle DE;Wilson NG;Baker BJ
对南极深水珊瑚的化学研究分离出四种新化合物，包括三种与alcyopterosins有关的illudalane倍半萜类化合物（1-3）、一种高度氧化的类固醇alcyosterone（5）和五种已知的alcyopterosins（4，6-9）。通过广泛的1D和2D NMR分析确定了结构，而9通过XRD验证。Alcyopterosins是不寻常的，其硝酸酯官能化，并已被表征为与其DNA结合特性相关的细胞毒性。Alcyopterosins V（3）和E（4）对艰难梭菌（Clostridium difficile）表现出个位数微摩尔活性，艰难梭菌是一种能够引起严重腹泻的肠道细菌，与耐药性越来越相关。Alcyosterone（5）和几种alcyopterosins对原生动物杜氏利什曼原虫（Leishmania donovani）也有类似的效力，杜氏利什曼原虫是利什曼病的病原体，利什曼病是一种如果不治疗可能致命的毁容疾病。虽然已知倍半萜的alcyopterosin家族具有轻度细胞毒性，但观察到的抗C. difficile和L. donovani对传染源有选择性。
Chemical investigation of an Antarctic deep-water octocoral has led to the isolation of four new compounds, including three illudalane sesquiterpenoids (1–3) related to the alcyopterosins, a highly oxidized steroid, alcyosterone (5), and five known alcyopterosins (4, 6–9). The structures were established by extensive 1D and 2D NMR analyses, while 9 was verified by XRD. Alcyopterosins are unusual for their nitrate ester functionalization and have been characterized with cytotoxicity related to their DNA binding properties. Alcyopterosins V (3) and E (4) demonstrated single-digit micromolar activity against Clostridium difficile, an intestinal bacterium capable of causing severe diarrhea that is increasingly associated with drug resistance. Alcyosterone (5) and several alcyopterosins were similarly potent against the protist Leishmania donovani, the causative agent of leishmaniasis, a disfiguring disease that can be fatal if not treated. While the alcyopterosin family of sesquiterpenes is known for mild cytotoxicity, the observed activity against C. difficile and L. donovani is selective for the infectious agents.
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影响因子：
2.6
作者：
Moore JM;Carvajal JI;Rouse GW;Wilson NG
通讯作者：
Wilson NG
影响因子：
3.4
作者：
Dueñas LF;Tracey DM;Crawford AJ;Wilke T;Alderslade P;Sánchez JA
通讯作者：
Sánchez JA
影响因子：
14.9
作者：
Trifinopoulos J;Nguyen LT;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
5.1
作者：
Thomas, Santana A. L.;von Salm, Jacqueline L.;Baker, Bill J.
通讯作者：
Baker, Bill J.
影响因子：
5.2
作者：
von Salm, Jacqueline L.;Wilson, Nerida G.;Vesely, Brian A.;Kyle, Dennis E.;Cuce, Jason;Baker, Bill J.
通讯作者：
Baker, Bill J.