Does chronic microaspiration cause idiopathic pulmonary fibrosis?
Does chronic microaspiration cause idiopathic pulmonary fibrosis?
复制标题
DOI：
10.1016/j.amjmed.2009.07.033
复制
发表时间：
2010-04
影响因子：
5.9
通讯作者：
King, Talmadge E., Jr.
中科院分区：
文献类型：
--
作者：
Lee, Joyce S.;Collard, Harold R.;Raghu, Ganesh;Sweet, Matthew P.;Hays, Steven R.;Campos, Guilherme M.;Golden, Jeffrey A.;King, Talmadge E., Jr.
关键词：
特发性肺纤维化是一种病因不明的弥漫性肺纤维化疾病，目前尚无有效的治疗方法。新出现的数据支持慢性微抽吸（即小液滴的亚临床抽吸）在特发性肺纤维化的发病机制和自然史中的作用。然而，慢性微抽吸和特发性肺纤维化之间的确切关系仍然未知。胃食管反流是微抽吸的假定风险因素，与特发性肺纤维化密切相关，估计患病率为90%。本文旨在通过阐述慢性微抽吸与特发性肺纤维化之间的关系的临床和生物学原理，并探索现有的科学证据，来描述慢性微抽吸与特发性肺纤维化之间的关系。我们目前对慢性微抽吸和特发性肺纤维化诊断的理解的差距以及管理和治疗方面的不确定性将得到强调。确定慢性微抽吸在特发性肺纤维化中的作用是至关重要的，因为它对这种致命疾病具有潜在的临床、病理生物学和治疗意义。
Idiopathic pulmonary fibrosis is a diffuse fibrotic lung disease of unknown etiology with no effective treatment. Emerging data support a role for chronic microaspiration (i.e. subclinical aspiration of small droplets) in the pathogenesis and natural history of idiopathic pulmonary fibrosis. However, the precise relationship between chronic microaspiration and idiopathic pulmonary fibrosis remains unknown. Gastroesophageal reflux, a presumed risk factor for microaspiration, has been strongly associated with idiopathic pulmonary fibrosis with an estimated prevalence of 90%. This review aims to describe the relationship between chronic microaspiration and idiopathic pulmonary fibrosis by laying out the clinical and biologic rationale for this relationship and exploring the scientific evidence available. The gaps in our current understanding of the diagnosis of chronic microaspiration and idiopathic pulmonary fibrosis and the ongoing uncertainties in management and treatment will be highlighted. Defining the role of chronic microaspiration in idiopathic pulmonary fibrosis is essential as it has potential clinical, pathobiological and treatment implications for this deadly disease.
登录
查看更多内容
DOI：
10.1164/rccm.200601-107oc
发表时间：
2007-02-01
影响因子：
24.7
作者：
Jackson, Abigail S.;Sandrini, Alessandra;Yates, Deborah H.
通讯作者：
Yates, Deborah H.
DOI：
10.1016/j.jtcvs.2004.10.035
发表时间：
2005-05-01
影响因子：
6
作者：
D'Ovidio, F;Mura, M;Keshavjee, S
通讯作者：
Keshavjee, S
影响因子：
6
作者：
Davis, RD;Lau, CL;Palmer, SM
通讯作者：
Palmer, SM
影响因子：
5.8
作者：
Appel JZ 3rd;Lee SM;Hartwig MG;Li B;Hsieh CC;Cantu E 3rd;Yoon Y;Lin SS;Parker W;Davis RD
通讯作者：
Davis RD
影响因子：
9.6
作者：
Gleeson, K;Eggli, DF;Maxwell, SL
通讯作者：
Maxwell, SL