Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications.

Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications.
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DOI:
10.1186/s13046-020-01765-x
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发表时间:
2020-11-30
期刊:
Journal of experimental & clinical cancer research : CR
影响因子:
--
通讯作者:
Cui R
Cui R
中科院分区:
其他
文献类型:
--
作者:
Cao L;Wu J;Qu X;Sheng J;Cui M;Liu S;Huang X;Xiang Y;Li B;Zhang X;Cui R

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Pancreatic cancer is one of the most malignant tumors worldwide, and pancreatic ductal adenocarcinoma is the most common type. In pancreatic cancer, glycolysis is the primary way energy is produced to maintain the proliferation, invasion, migration, and metastasis of cancer cells, even under normoxia. However, the potential molecular mechanism is still unknown. From this perspective, this review mainly aimed to summarize the current reasonable interpretation of aerobic glycolysis in pancreatic cancer and some of the newest methods for the detection and treatment of pancreatic cancer. More specifically, we reported some biochemical parameters, such as newly developed enzymes and transporters, and further explored their potential as diagnostic biomarkers and therapeutic targets.
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