Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG.
Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG.
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DOI：
10.1038/nature02675
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发表时间：
2004-07-22
期刊：
影响因子：
64.8
通讯作者：
Bates, PA
中科院分区：
文献类型：
--
作者：
Rogers, ME;Ilg, T;Nikolaev, AV;Ferguson, MAJ;Bates, PA
白蛉是原生动物寄生虫利什曼原虫的唯一媒介，但通过苍蝇叮咬传播的机制尚未确定，也未纳入感染的实验模型。在具有成熟利什曼原虫感染的白蛉中，前中肠被寄生虫来源的凝胶，前鞭毛体分泌凝胶（PSG）阻断。在这里，我们分析了第一次从墨西哥利什曼原虫感染Lutzomyia longipalpis沙蝇接种。这揭示了感染剂量的大小、寄生虫通过反流传递的潜在机制，以及丝状蛋白磷聚糖（fPPG）对感染的新贡献，fPPG是发现在传播过程中伴随寄生虫的PSG成分。总的来说，这些结果对于了解寄生虫及其载体之间的关系，人类皮肤利什曼病的病理学以及有效疫苗和药物的开发具有重要意义。这些研究结果强调，要充分了解病媒传播疾病的传播，必须考虑所有三个参与者之间的相互作用。
Sand flies are the exclusive vectors of the protozoan parasite Leishmania, but the mechanism of transmission by fly bite has not been determined nor incorporated into experimental models of infection. In sand flies with mature Leishmania infections the anterior midgut is blocked by a gel of parasite origin, the promastigote secretory gel (PSG). Here, we analyse for the first time the inocula from Leishmania mexicana infected Lutzomyia longipalpis sand flies. This revealed the size of the infectious dose, the underlying mechanism of parasite delivery by regurgitation, and the novel contribution made to infection by filamentous proteophosphoglycan (fPPG), a component of PSG found to accompany the parasites during transmission. Collectively, these results have important implications for understanding the relationship between parasite and its vector, the pathology of cutaneous leishmaniasis in humans and also the development of effective vaccines and drugs. These findings emphasise that to fully understand transmission of vector-borne diseases the interaction between all three participants must be considered.
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DOI：
10.1084/jem.188.10.1941
发表时间：
1998-11-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Belkaid Y;Kamhawi S;Modi G;Valenzuela J;Noben-Trauth N;Rowton E;Ribeiro J;Sacks DL
通讯作者：
Sacks DL
影响因子：
4.8
作者：
Ilg, T;Stierhof, YD;Bacic, A
通讯作者：
Bacic, A
DOI：
10.1073/pnas.160257897
发表时间：
2000-08-01
影响因子：
11.1
作者：
Späth, GF;Epstein, L;Beverley, SM
通讯作者：
Beverley, SM
DOI：
10.4269/ajtmh.1986.35.926
发表时间：
1986-09-01
影响因子：
3.3
作者：
WARBURG, A;SCHLEIN, Y
通讯作者：
SCHLEIN, Y
DOI：
10.4269/ajtmh.1985.34.278
发表时间：
1985-01-01
影响因子：
3.3
作者：
BEACH, R;KIILU, G;LEEUWENBURG, J
通讯作者：
LEEUWENBURG, J