Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2.
Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2.
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DOI：
10.1177/0022034520967933
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发表时间：
2021-03
影响因子：
7.6
通讯作者：
Bourgeois D
中科院分区：
文献类型：
--
作者：
Carrouel F;Gonçalves LS;Conte MP;Campus G;Fisher J;Fraticelli L;Gadea-Deschamps E;Ottolenghi L;Bourgeois D
口腔是上呼吸道的重要组成部分，在SARS-CoV-2的致病和传播中起着重要作用。确定有针对性的抗病毒漱口水以减少唾液病毒载量将有助于减少新冠肺炎的大流行。在等待迄今尚不存在的重大临床研究结果的同时，口腔漱口水的商业化可获得性使我们在其中寻找与SARS-CoV-2相关的具有特定抗病毒特性的试剂。对在ClinicalTrials.gov网站上列出的在市面上可买到的口腔漱口水中发现的7种试剂面临的挑战进行了审查：聚维酮碘、洗必泰、过氧化氢、环糊精、柠檬酸、氯化十六烷基吡啶和精油。由于SARS-CoV-2是一种包膜病毒，许多试剂针对的是外膜脂膜。此外，它们中的一些可以通过变性蛋白质作用于衣壳。到目前为止，还没有科学证据推荐具有抗SARS-CoV-2效果的漱口水来控制口腔中的病毒载量。这一关键的综述表明，目前对这些试剂的了解可能会改善唾液病毒载量状态的趋势。这一发现是鼓励临床研究的一个强烈迹象，文献中已经有了高质量的方案。
The oral cavity, an essential part of the upper aerodigestive tract, is believed to play an important role in the pathogenicity and transmission of SARS-CoV-2. The identification of targeted antiviral mouth rinses to reduce salivary viral load would contribute to reducing the COVID-19 pandemic. While awaiting the results of significant clinical studies, which to date do not exist, the commercial availability of mouth rinses leads us to search among them for reagents that would have specific antiviral properties with respect to SARS-CoV-2. The challenges facing this target were examined for 7 reagents found in commercially available mouth rinses and listed on the ClinicalTrials.gov website: povidone-iodine, chlorhexidine, hydrogen peroxide, cyclodextrin, Citrox, cetylpyridinium chloride, and essential oils. Because SARS-CoV-2 is an enveloped virus, many reagents target the outer lipid membrane. Moreover, some of them can act on the capsid by denaturing proteins. Until now, there has been no scientific evidence to recommend mouth rinses with an anti–SARS-CoV-2 effect to control the viral load in the oral cavity. This critical review indicates that current knowledge of these reagents would likely improve trends in salivary viral load status. This finding is a strong sign to encourage clinical research for which quality protocols are already available in the literature.
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影响因子：
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