Demographic and clinical features of dengue fever in Pakistan from 2003-2007: a retrospective cross-sectional study.
Demographic and clinical features of dengue fever in Pakistan from 2003-2007: a retrospective cross-sectional study.
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DOI：
10.1371/journal.pone.0012505
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发表时间：
2010-09-13
期刊：
影响因子：
3.7
通讯作者：
Hasan R
中科院分区：
文献类型：
--
作者：
Khan E;Kisat M;Khan N;Nasir A;Ayub S;Hasan R
过去二十年来，巴基斯坦登革热的人口特征发生了巨大变化。来自全国各地的小规模研究报告了这段时间内个别疫情的不同方面。然而，缺乏有关该国登革热病毒感染总体趋势的数据。在这项研究中，我们研究了巴基斯坦人群登革热的年度趋势，季节性和临床特征。分析了2003年1月至2007年12月在阿加汗大学医院检测登革热IgM抗体的所有患者的人口统计学信息和登革热IgM状态，以寻找巴基斯坦IgM阳性病例的趋势。此外，从2006年1月至2007年12月期间因IgM确诊登革热住院的所有患者的病历中回顾性提取临床和生化参数。根据WHO严重程度分级标准将这些患者分为登革热和登革出血热。在总共15040名患者（63.2%男性和36.8%女性）中，3952名（26.3%）登革热IgM抗体检测呈阳性。在研究期间，209名IgM确诊的登革热患者住院。2003年，IgM抗体阳性病例仅在7月至12月出现。相比之下，2004-2007年全年都发现了此类案件。IgM阳性患者的中位年龄逐年下降，从2003年的32.0岁降至2007年的24.0岁（p<0.001）。在住院患者中，恶心是124/209（59.3%）例患者中最常见的表现特征。儿童的中位体温高于成人（p = 0.010）。 此外，中性粒细胞减少症在儿童中更常见，而血清ALT水平升高在成人中更常见（均p = 0.006）。 虽然与登革出血热患者相比，登革热患者中总白色细胞计数较低更常见（p = 0.020），但在登革出血热患者中，中性粒细胞减少症（p = 0.019）、单核细胞增多症（p = 0.001）和血清ALT水平升高（p = 0.005）更常见。 登革热病毒现在在巴基斯坦流行，全年传播，在季风后时期发病率最高。登革热患者的中位年龄已经下降，年轻患者可能更容易受到影响。白细胞总数和分类计数可能有助于识别有出血风险的患者。
Demographic features of dengue fever have changed tremendously in Pakistan over the past two decades. Small scale studies from all over the country have reported different aspects of individual outbreaks during this time. However, there is scarcity of data looking at the overall trend of dengue virus infection in the country. In this study, we examined annual trends, seasonality, and clinical features of dengue fever in the Pakistani population. Demographic information and dengue IgM status of all patients tested for dengue IgM antibody at Aga Khan University Hospital from January 2003 to December 2007 were analyzed to look for trends of IgM-positive cases in Pakistan. In addition, clinical and biochemical parameters were abstracted retrospectively from medical records of all patients hospitalized with IgM-proven dengue fever between January 2006 and December 2007. These patients were categorized into dengue fever and dengue hemorrhagic fever according to the WHO severity grading scale. Out of a total of 15040 patients (63.2% male and 36.8% female), 3952 (26.3%) tested positive for dengue IgM antibody. 209 IgM proven dengue patients were hospitalized during the study period. During 2003, IgM positive cases were seen only during the months of July-December. In contrast, such cases were detected throughout the year from the 2004–2007. The median age of IgM positive patients decreased every year from 32.0 years in 2003 to 24.0 years in 2007 (p<0.001). Among hospitalized patients, nausea was the most common presenting feature found in 124/209 (59.3%) patients. Children presented with a higher median body temperature than adults (p = 0.010). In addition, neutropenia was seen more commonly in children while raised serum ALT levels were seen more commonly in adults (both p = 0.006). While a low total white cell count was more common in patients with dengue fever as compared to Dengue Hemorrhagic Fever (p = 0.020), neutropenia (p = 0.019), monocytosis (p = 0.001) and raised serum ALT level (p = 0.005) were observed more commonly in the latter group. Dengue virus is now endemic in Pakistan, circulating throughout the year with a peak incidence in the post monsoon period. Median age of dengue patients has decreased and younger patients may be more susceptible. Total and differential leukocyte counts may help identify patients at risk of hemorrhage.
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影响因子：
11.8
作者：
Potter P
通讯作者：
Potter P
影响因子：
4.3
作者：
Akram, Dure Samin;Igarashi, Akira;Takasu, T.
通讯作者：
Takasu, T.
影响因子：
5.4
作者：
Keating, J
通讯作者：
Keating, J
DOI：
10.1016/s1201-9712(98)90052-2
发表时间：
1998-04-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Paul, R E;Patel, A Y;Luby, S P
通讯作者：
Luby, S P
影响因子：
3.3
作者：
Murgue, B;Deparis, X;Roche, C
通讯作者：
Roche, C