Aquatic Exposure to Abscisic Acid Transstadially Enhances Anopheles stephensi Resistance to Malaria Parasite Infection.
Aquatic Exposure to Abscisic Acid Transstadially Enhances Anopheles stephensi Resistance to Malaria Parasite Infection.
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DOI：
10.3390/genes11121393
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发表时间：
2020-11-24
期刊：
影响因子：
3.5
通讯作者：
Luckhart S
中科院分区：
文献类型：
--
作者：
Taylor DM;Haney RS;Luckhart S
古老的胁迫信号分子脱落酸(ABA)在动植物中普遍存在，但最广为人知的可能是它作为一种植物激素的早期发现。ABA可以被植物释放到水中，存在于花蜜中，但也存在于哺乳动物的血液中，这是蚊子生物学的三个关键背景。我们先前证实，在斯氏按蚊幼虫饲养水中添加ABA改变了来自处理幼虫的雌性幼虫的未成熟发育和生活史特征，而在受感染的血粉中添加ABA则增加了斯氏按蚊成年雌性对人类疟疾寄生虫感染的抵抗力。在这里，我们试图确定用ABA处理幼虫是否同样会影响来自处理幼虫的雌性幼虫对寄生虫感染的抵抗力，如果是的话，抵抗力是否可以扩展到另一种寄生虫物种。我们研究了营养水平和基因表达，以证明ABA可以通过途径改变对啮齿动物疟疾寄生虫的抵抗力，具有先前观察到的抵抗机制的特征，即在血液中提供ABA给斯氏疟原虫。
The ancient stress signaling molecule abscisic acid (ABA) is ubiquitous in animals and plants but is perhaps most well-known from its early discovery as a plant hormone. ABA can be released into water by plants and is found in nectar, but is also present in mammalian blood, three key contexts for mosquito biology. We previously established that addition of ABA to Anopheles stephensi larval rearing water altered immature development and life history traits of females derived from treated larvae, while addition of ABA to an infected bloodmeal increased resistance of adult female A. stephensi to human malaria parasite infection. Here we sought to determine whether larval treatment with ABA could similarly impact resistance to parasite infection in females derived from treated larvae and, if so, whether resistance could be extended to another parasite species. We examined nutrient levels and gene expression to demonstrate that ABA can transstadially alter resistance to a rodent malaria parasite with hallmarks of previously observed mechanisms of resistance following provision of ABA in blood to A. stephensi.
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