Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene.
Neural and behavioral responses to threatening emotion faces in children as a function of the short allele of the serotonin transporter gene.
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DOI：
10.1016/j.biopsycho.2010.04.009
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发表时间：
2010-09
影响因子：
2.6
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Thomason, Moriah E.;Henry, Melissa L.;Hamilton, J. Paul;Joormann, Jutta;Pine, Daniel S.;Ernst, Monique;Goldman, David;Mogg, Karin;Bradley, Brendan P.;Britton, Jennifer C.;Lindstrom, Kara M.;Monk, Christopher S.;Sankin, Lindsey S.;Louro, Hugo M. C.;Gotlib, Ian H.
最近的证据表明，成人血清素转运基因（SLC6A4）的启动子区域（5-HTTLPR）的遗传多态性介导应激反应。然而，人们对儿童和青少年时期的这种基因与大脑的关联知之甚少，这通常被认为是应激反应增强的时期。本研究考察了5-HTTLPR等位基因变异与9-17岁参与者对恐惧和愤怒面孔的反应之间的关系。行为上，5-HTTLPR短等位基因的携带者比长等位基因纯合的携带者对下意识呈现的恐惧面孔表现出更大的注意偏向。此外，s等位基因携带者比l等位基因纯合子在先前与成年人注意力控制相关的联合皮层的各个区域显示出更大的神经激活。这些结果表明，在儿童和青少年中，s等位基因携带者和l等位基因纯合子可以根据对负性物质的过度警惕的行为和神经处理来区分。
Recent evidence suggests that a genetic polymorphism in the promoter region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) mediates stress reactivity in adults. Little is known, however, about this gene-brain association in childhood and adolescence, generally conceptualized as a time of heightened stress reactivity. The present study examines the association between 5-HTTLPR allelic variation and responses to fearful and angry faces presented both sub- and supraliminally in participants, ages 9–17. Behaviorally, carriers of the 5-HTTLPR short (s) allele exhibited significantly greater attentional bias to subliminally presented fear faces than did their long (l)-allele homozygous counterparts. Moreover, s-allele carriers showed greater neural activations to fearful and angry faces than did l-allele homozygotes in various regions of association cortex previously linked to attention control in adults. These results indicate that in children and adolescents, s-allele carriers can be distinguished from l-allele homozygotes on the basis of hypervigilant behavioral and neural processing of negative material.
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影响因子：
11
作者：
通讯作者：
--
DOI：
10.1080/15374410902851705
发表时间：
2009-05
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
--
作者：
Gibb BE;Benas JS;Grassia M;McGeary J
通讯作者：
McGeary J
影响因子：
4.6
作者：
Joormann, Jutta;Talbot, Lisa;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
DOI：
10.1097/00004583-200104000-00014
发表时间：
2001-04-01
影响因子：
13.3
作者：
Geller, B;Zimerman, B;Soutullo, C
通讯作者：
Soutullo, C
影响因子：
4.1
作者：
Eldar, Sharon;Ricon, Tsameret;Bar-Haim, Yair
通讯作者：
Bar-Haim, Yair