A Discrete Choice Analysis Comparing COVID-19 Vaccination Decisions for Children and Adults.
A Discrete Choice Analysis Comparing COVID-19 Vaccination Decisions for Children and Adults.
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DOI：
10.1001/jamanetworkopen.2022.53582
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发表时间：
2023-01-03
影响因子：
13.8
通讯作者：
Pike, Jamison
中科院分区：
文献类型：
--
作者：
Prosser, Lisa A.;Wagner, Abram L.;Wittenberg, Eve;Zikmund-Fisher, Brian J.;Rose, Angela M.;Pike, Jamison
这项调查研究评估了美国成年人对成人和儿童新冠肺炎疫苗接种属性的偏好。儿童和成人接种新冠肺炎疫苗的偏好是否有所不同？在这项对1040名美国成年人的调查研究中，所有的属性(疫苗有效性、轻微的副作用、罕见的不良事件、剂量、监管批准、等待时间)都是选择接种的重要因素，在比较成人和儿童疫苗接种时，差异很小。潜伏期分析确定了4个不同的亚组，包括1个对便利性(等待时间和剂量数量)敏感的亚组。这些发现表明，提供更方便的疫苗接种选择可能是一种可行的战略，以增加人口亚群的疫苗接种率。美国的新冠肺炎接种率仍低于最佳水平。患者对不同属性的疫苗产品的偏好和疫苗接种经验在决定疫苗接种决策时可能很重要。评估美国成年人对成人和儿童新冠肺炎疫苗接种属性的偏好。2021年5月和6月，对1040名美国成年人进行了一项在线调查。离散选择分析被用来衡量成人或儿童选择新冠肺炎疫苗接种选项的决策中每个属性的相对值。六个属性被用来描述假想的疫苗接种选项：疫苗有效性、轻微的副作用、罕见的不良事件、剂量、接种所需的时间和监管批准。受访者在假想的疫苗接种情况或不接种疫苗之间进行选择。其他调查问题包括接种疫苗的信念、患新冠肺炎的经历、新冠肺炎的风险因素、接种疫苗的状况以及对新冠肺炎风险的看法。受访者选择他们更愿意为自己接种哪种疫苗(或不接种疫苗)。然后，受访者考虑了一组相同的0至17岁假想儿童的个人资料。用贝叶斯Logit回归估计疫苗接种相关属性的相对值。使用潜在类别分析来估计亚组的偏好分布。共有1040名成年人(610名[59%]女性；379名年龄在55岁及以上的参与者[36%])回答了这项调查。当被问及自己的疫苗接种选择时，参与者表示疫苗有效性(95%比60%)是一个重要属性(β，9.59[95%CRI，9.20-10.00]vsβ，0.41[95%CRI，0-0.80])。受访者还倾向于较少的罕见不良事件(β，6.35[95%CRI5.74-6.86)，较少的轻微副作用(β，5.49；95%CRI5.12-5.87)，一剂(β，5.41；95%CRI5.04-5.78)，FDA批准(β，6.01；95%CRI5.64-6.41)，以及较短的等待时间(β，5.67；95%CRI4.87-6.48)。当将问题框定为成人或儿童疫苗时，结果非常相似，略微更倾向于儿童较少的罕见不良事件。潜在类别分析揭示了4组受访者：(1)对安全和监管状况敏感的个人，(2)对便利敏感的个人，(3)在做出选择时仔细考虑所有属性的个人，以及(4)拒绝接种疫苗的个人。在这项针对美国成年人的调查研究中，确定了4个不同的偏好群体，为指导沟通以支持疫苗决策提供了新的信息。特别是，优先考虑便利性的群体(接种疫苗所需的时间和剂量较少)可能提供一个机会，以制定可行的战略，提高成人和儿童人口的疫苗接种率。
This survey study assesses preferences for attributes of adult and pediatric COVID-19 vaccination among US adults. Do preferences for COVID-19 vaccination vary across pediatric and adult vaccination? In this survey study of 1040 US adults, all included attributes (vaccine effectiveness, mild side effects, rare adverse events, number of doses, regulatory approval, waiting time) were important factors in choosing to vaccinate with little difference in magnitude when comparing adult and pediatric vaccination. Latent class analyses identified 4 distinct subgroups, including 1 subgroup sensitive to convenience (waiting time and number of doses). These findings suggest that providing more convenient vaccination options may represent an actionable strategy to increase vaccination uptake for a subgroup of the population. COVID-19 vaccination rates in the US remain below optimal levels. Patient preferences for different attributes of vaccine products and the vaccination experience can be important in determining vaccine uptake decisions. To assess preferences for attributes of adult and pediatric COVID-19 vaccination among US adults. An online survey of a national panel of 1040 US adults was conducted in May and June 2021. A discrete choice analysis was used to measure the relative value of each attribute in the decision to choose a COVID-19 vaccination option for adults or children. Six attributes were used to described hypothetical vaccination options: vaccine effectiveness, mild side effects, rare adverse events, number of doses, time required for vaccination, and regulatory approval. Respondents chose between hypothetical vaccination profiles or no vaccination. Additional survey questions asked about vaccination beliefs, COVID-19 illness experience, COVID-19 risk factors, vaccination status, and opinions about the risk of COVID-19. Respondents chose which vaccine profile they would prefer to receive for themselves (or no vaccination). Respondents then considered an identical set of profiles for a hypothetical child aged 0 to 17 years. Relative value of vaccination-related attributes were estimated using Bayesian logit regression. Preference profiles for subgroups were estimated using latent class analyses. A total of 1040 adults (610 [59%] female; 379 participants [36%] with an age of 55 years and older years) responded to the survey. When asked about vaccination choices for themselves, participants indicated that vaccine effectiveness (95% vs 60%) was a significant attribute (β, 9.59 [95% CrI, 9.20-10.00] vs β, 0.41 [95% CrI, 0-0.80]). Respondents also preferred fewer rare adverse events (β, 6.35 [95% CrI, 5.74-6.86), fewer mild side effects (β, 5.49; 95% CrI, 5.12-5.87), 1 dose (β, 5.41; 95% CrI, 5.04-5.78), FDA approval (β, 6.01; 95% CrI, 5.64-6.41), and shorter waiting times (β, 5.67; 95% CrI, 4.87-6.48). Results were very similar when framing the question as adult or child vaccination, with slightly stronger preference for fewer rare adverse events for children. Latent class analysis revealed 4 groups of respondents: (1) individuals sensitive to safety and regulatory status, (2) individuals sensitive to convenience, (3) individuals who carefully considered all attributes in making their choices, and (4) individuals who rejected the vaccine. In this survey study of US adults, the identification of 4 distinct preference groups provides new information to guide communications to support vaccine decision making. In particular, the group that prioritize convenience (less time required for vaccination and fewer doses) may present an opportunity to create actionable strategies to increase vaccination uptake for both adult and pediatric populations.
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影响因子：
3.7
作者：
Eshun-Wilson I;Mody A;Tram KH;Bradley C;Sheve A;Fox B;Thompson V;Geng EH
通讯作者：
Geng EH
DOI：
10.2165/11587340-000000000-00000
发表时间：
2011-05-01
影响因子：
3.6
作者：
Eisenberg, Daniel;Freed, Gary;Prosser, Lisa
通讯作者：
Prosser, Lisa
DOI：
10.1177/0272989x15581805
发表时间：
2015-08
期刊：
Medical decision making : an international journal of the Society for Medical Decision Making
影响因子：
--
作者：
Lipstein EA;Britto MT
通讯作者：
Britto MT
影响因子：
5.5
作者：
Nguyen KH;Srivastav A;Lindley MC;Fisher A;Kim D;Greby SM;Lee J;Singleton JA
通讯作者：
Singleton JA
影响因子：
4.5
作者：
Johnson, F. Reed;Lancsar, Emily;Bridges, John F. P.
通讯作者：
Bridges, John F. P.