Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis.
Omega-3 fatty acid supplementation for the treatment of children with attention-deficit/hyperactivity disorder symptomatology: systematic review and meta-analysis.
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DOI：
10.1016/j.jaac.2011.06.008
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发表时间：
2011-10
影响因子：
13.3
通讯作者：
Qawasmi A
中科院分区：
文献类型：
--
作者：
Bloch MH;Qawasmi A
几项研究表明，与未受影响的对照组相比，ADHD患者血浆和红细胞膜中的omega-3脂肪酸组成存在差异。Omega-3脂肪酸具有抗炎特性，可以改变中枢神经系统细胞膜的流动性和磷脂成分。细胞膜流动性可以改变血清素和多巴胺的神经传递。这项荟萃分析的目的是检查omega-3脂肪酸补充剂对ADHD儿童的疗效。我们在PubMED中搜索了随机、安慰剂对照试验，这些试验检查了ADHD儿童的omega-3脂肪酸补充剂。我们的主要结果测量是ADHD严重程度评定量表的标准化平均差。我们进行了二次分析，以确定补充剂中不同omega-3脂肪酸剂量的影响。本荟萃分析纳入了10项试验，涉及699名儿童。Omega-3脂肪酸补充剂在改善ADHD症状方面表现出较小但显著的效果。补充剂中的二十碳五烯酸（EPA）剂量与补充剂功效显著相关。我们没有发现发表偏倚或试验间异质性的证据。补充Omega-3脂肪酸，特别是高剂量的EPA，在治疗ADHD方面有一定的效果。与目前可用的ADHD药物治疗（如精神兴奋剂、托莫西汀或α-2激动剂）相比，ω-3脂肪酸补充剂的相对疗效适中。然而，鉴于其相对良性的副作用和适度疗效的证据，使用omega-3脂肪补充剂来加强传统的药物干预或拒绝其他精神药理学选择的家庭可能是合理的。
Several studies have demonstrated differences in omega-3 fatty acid composition in plasma and in erythrocyte membranes in patients with ADHD compared to unaffected controls. Omega-3 fatty acids have anti-inflammatory properties and can alter central nervous system cell membrane fluidity and phospholipid composition. Cell membrane fluidity can alter serotonin and dopamine neurotransmission. The goal of this meta-analysis is to examine the efficacy of omega-3 fatty acid supplementation in children with ADHD. We searched PubMED for randomized, placebo-controlled trials examining omega-3 fatty acid supplementation in children with ADHD symptomatology. Our primary outcome measure was standardized mean difference in rating scales of ADHD severity. We conducted secondary analyses to determine the effects of dosing of different omega-3 fatty acids in supplements. Ten trials involving 699 children were included in this meta-analysis. Omega-3 fatty acid supplementation demonstrated a small, but significant effect in improving ADHD symptoms. Eicosapentaenoic acid (EPA) dose within supplements was significantly correlated with supplement efficacy. We found no evidence of publication bias or heterogeneity between trials. Omega-3 fatty acid supplementation, particularly with higher doses of EPA, was modestly effective in the treatment of ADHD. The relative efficacy of omega-3 fatty acid supplementation was modest compared to currently available pharmacotherapies for ADHD such as psychostimulants, atomoxetine or alpha-2 agonists. However, given its relatively benign side-effect profile and evidence of modest efficacy, it may be reasonable to use omega-3 fatty supplementation to augment traditional pharmacological interventions or for families who decline other psychopharmacological options.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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发表时间：
2009-07-01
影响因子：
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作者：
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通讯作者：
Erkkila, Arja T.