Thermosensitive multilayer hydrogels of poly(N-vinylcaprolactam) as nanothin films and shaped capsules.
Thermosensitive multilayer hydrogels of poly(N-vinylcaprolactam) as nanothin films and shaped capsules.
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DOI：
10.1021/cm301657q
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发表时间：
2012-08-09
影响因子：
8.6
通讯作者：
Kharlampieva, Eugenia
中科院分区：
文献类型：
--
作者：
Liang, Xing;Kozlovskaya, Veronika;Chen, Yi;Zavgorodnya, Oleksandra;Kharlampieva, Eugenia
我们报道了交联聚（N-乙烯基己内酰胺）（PVCL）的纳米薄膜多层水凝胶，其表现出独特的和可逆的温敏行为。通过PVCL与聚甲基丙烯酸（PMAA）的氢键作用，在PVCL-NH 2共聚物的逐层膜中选择性交联PVCL，制备单组分PVCL水凝胶。对于由PVCL-NH 2 -7和PVCL-NH 2 -14共聚物制成的膜，PVCL水凝胶膜收缩程度（定义为在25°C与50°C下的湿厚度的比率）被证明分别为1.9±0.1和1.3±0.1。由于PMAA的存在，未观察到非交联双组分膜的温度响应行为。我们还表明，温度敏感的PVCL胶囊的立方体和球形的形状可以制造为中空的无机模板的水凝胶副本。当温度从25°C升高至50°C时，立方体（PVCL）7胶囊保持其立方体形状，表现出胶囊尺寸减小21±1%。球形水凝胶胶囊表现出相似的收缩率23± 1%。温度触发的胶囊大小变化是完全可逆的。我们的工作为开发生物相容性和纳米薄膜水凝胶涂层和容器开辟了新的前景，用于微流体设备中的温度调节药物递送，细胞摄取，传感和运输行为。
We report on nanothin multilayer hydrogels of cross-linked poly(N-vinylcaprolactam) (PVCL) that exhibit distinctive and reversible thermoresponsive behavior. The single-component PVCL hydrogels were produced by selective cross-linking of PVCL in layer-by-layer films of PVCL-NH2 copolymers assembled with poly(methacrylic acid) (PMAA) via hydrogen bonding. The degree of the PVCL hydrogel film shrinkage, defined as the ratio of wet thicknesses at 25°C to 50°C, was demonstrated to be 1.9±0.1 and 1.3±0.1 for the films made from PVCL-NH2-7 and PVCL-NH2-14 copolymers, respectively. No temperature-responsive behavior was observed for non-cross-linked two-component films due to the presence of PMAA. We also demonstrated that temperature-sensitive PVCL capsules of cubical and spherical shapes could be fabricated as hollow hydrogel replicas of inorganic templates. The cubical (PVCL)7 capsules retained their cubical shape when temperature was elevated from 25°C to 50°C exhibiting 21±1% decrease in the capsule size. Spherical hydrogel capsules demonstrated similar shrinkage of 23±1%. The temperature-triggered capsule size changes were completely reversible. Our work opens new prospects for developing biocompatible and nanothin hydrogel-based coatings and containers for temperate-regulating drug delivery, cellular uptake, sensing, and transport behavior in microfluidic devices.
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影响因子：
29.4
作者：
Kharlampieva, Eugenia;Kozlovskaya, Veronika;Sukhishvili, Svetlana A.
通讯作者：
Sukhishvili, Svetlana A.
影响因子：
5.5
作者：
Erel-Unal, Irem;Sukhishvili, Svetlana A.
通讯作者：
Sukhishvili, Svetlana A.
影响因子：
3.9
作者：
Chong, Siow-Feng;Lee, Ji Hyun;Caruso, Frank
通讯作者：
Caruso, Frank
影响因子：
2.5
作者：
Glinel, K;Sukhorukov, GB;Tauer, K
通讯作者：
Tauer, K
影响因子：
5.5
作者：
Balaceanu, Andreea;Demco, Dan E.;Pich, Andrij
通讯作者：
Pich, Andrij