Skin Microbiota Variation Among Bat Species in China and Their Potential Defense Against Pathogens.
Skin Microbiota Variation Among Bat Species in China and Their Potential Defense Against Pathogens.
复制标题
中国蝙蝠物种皮肤微生物群的变化及其对病原体的潜在防御能力
DOI：
10.3389/fmicb.2022.808788
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Feng, Jiang
中科院分区：
文献类型：
--
作者：
Li, Zhongle;Li, Aoqiang;Dai, Wentao;Leng, Haixia;Liu, Sen;Jin, Longru;Sun, Keping;Feng, Jiang
宿主相关的皮肤细菌对抵抗病原体感染和维持健康至关重要。然而，我们对翼手类皮肤微生物群在蝙蝠物种及其栖息地中的分布情况，以及它们在中国抵御破坏性假裸鼠中的作用知之甚少。在这项研究中，我们利用16S rRNA基因扩增子测序对4种蝙蝠在5个地点的皮肤微生物组进行了表征，以了解它们的皮肤微生物组成、结构以及与疾病的可能关系。不同种类蝙蝠皮肤微生物群α -和β -多样性存在显著差异，这种差异受环境温度、采样地点和宿主身体状况的影响。翼手类皮肤微生物群落富集在环境中相对丰度较低的细菌类群中。蝙蝠皮肤微生物群的大部分潜在功能与代谢有关。重点关注其防御病原体的功能，我们发现皮肤微生物群可以代谢多种活性物质，这些活性物质可能被用于对抗P. destructans。中国蝙蝠皮肤微生物群落与环境和蝙蝠宿主有关，可能参与宿主对病原体的防御。
Host-associated skin bacteria are essential for resisting pathogen infections and maintaining health. However, we have little understanding of how chiropteran skin microbiota are distributed among bat species and their habitats, or of their putative roles in defending against Pseudogymnoascus destructans in China. In this study, we characterized the skin microbiomes of four bat species at five localities using 16S rRNA gene amplicon sequencing to understand their skin microbial composition, structure, and putative relationship with disease. The alpha- and beta-diversities of skin microbiota differed significantly among the bat species, and the differences were affected by environmental temperature, sampling sites, and host body condition. The chiropteran skin microbial communities were enriched in bacterial taxa that had low relative abundances in the environment. Most of the potential functions of skin microbiota in bat species were associated with metabolism. Focusing on their functions of defense against pathogens, we found that skin microbiota could metabolize a variety of active substances that could be potentially used to fight P. destructans. The skin microbial communities of bats in China are related to the environment and the bat host, and may be involved in the host’s defense against pathogens.
登录
查看更多内容
影响因子：
16.6
作者：
Bates KA;Clare FC;O'Hanlon S;Bosch J;Brookes L;Hopkins K;McLaughlin EJ;Daniel O;Garner TWJ;Fisher MC;Harrison XA
通讯作者：
Harrison XA
影响因子：
6.7
作者：
Fu, Hai-Gen;Hu, Xin-Xin;Song, Dan-Qing
通讯作者：
Song, Dan-Qing
影响因子：
4.4
作者：
Beaumont, Martin;Cauquil, Laurent;Combes, Sylvie
通讯作者：
Combes, Sylvie
影响因子：
4.2
作者：
Grisnik, Matthew;Bowers, Olivia;Walker, Donald M.
通讯作者：
Walker, Donald M.
影响因子：
4.2
作者：
Fitzpatrick, Benjamin M.;Allison, Amanda L.
通讯作者：
Allison, Amanda L.