The impact of SARS-COV-2 infection on menstruation.
The impact of SARS-COV-2 infection on menstruation.
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DOI：
10.1186/s12905-023-02697-2
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发表时间：
2023-11-16
影响因子：
2.5
通讯作者：
Xie, Meiqing
中科院分区：
文献类型：
--
作者：
Zhong, Xiaozhu;Lu, Keji;Liang, Weiying;Jihu, Luozi;Zeng, Anqi;Ding, Miao;Chen, Dongmei;Xie, Meiqing
最近的研究表明，SARS-CoV-2可能会影响COVID后综合征患者的GnRH系统。然而，COVID-19感染对女性月经的影响仍是未知数。我们的目的是调查2019年冠状病毒病（COVID-19）与绝经前妇女月经之间的关系。这是一项回顾性队列研究。绝经前妇女被邀请参与微信在线问卷调查。参与者根据是否感染了严重急性呼吸综合征冠状病毒-2（SARS-COV-2）以及在大流行期间是否有月经变化被分为四组。收集了参与者的社会人口学特征、COVID-19病史、月经和月经变化。使用SPSS 25.0版（SPSS Inc.，芝加哥，IL，美国）。共有1946名女性被纳入研究。1800名参与者已经或正在感染SARS-COV-2，146人未被感染。在1800例COVID-19患者中，666例（37.0%）有月经变化，1134例（63.0%）无月经变化，显著高于未感染者（c2 = 12.161，P = 0.000）。月经周期改变的比例（450/67.6%）高于未感染者（c2 = 6.904，P = 0.009）。COVID-19疫苗接种与月经周期改变的几率较低相关（OR，0.855; 95%CI，0.750-0.976）。在感染期间报告胸痛（OR，1.750，95%CI，1.209-2.533）和呼吸困难（OR，1.446; 95%CI，1.052-1.988）的参与者与未报告的参与者相比，其月经周期变化的几率更大。COVID-19与月经周期不规则患病率增加之间的关联。COVID-19疫苗接种是长期的保护因素，胸痛和呼吸困难的参与者更容易发生AUB。
Recent study has demonstrated that the GnRH system in patients with post-COVID syndrome may be influenced by SARS-CoV-2. However, the impact of COVID-19 infection on women’s menstruation is still unknown. We aimed to investigate the the relationship between coronavirus disease 2019 (COVID-19) and menstruation in premenopausal women. This was a retrospective cohort study. Pre-menopausal women were invited to participate in the online questionnaire on wechat. Participants were divided into four groups according to whether they were infected with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and whether they had menstrual changes during the pandemic. Sociodemographic characteristics, history of COVID-19, menstruation and menstrual changes of the participants were collected. Statistical analyses were performed using SPSS, version 25.0 (SPSS Inc., Chicago, IL, USA). A total of 1946 women were included in the study. 1800 participants had been or were currently infected with SARS-COV-2, and 146 people had not been infected. Among 1800 patients with COVID-19, 666 (37.0%) had changes in menstruation, and 1134 (63.0%) did not, which was significantly higher than the uninfected participants (c2 = 12.161, P = 0.000). The proportion of participants with menstrual cycle changes (450/67.6%) is larger than that of uninfected participants (c2 = 6.904, P = 0.009). COVID-19 vaccination was associated with lower odds of menstrual cycle change (OR, 0.855; 95% CI, 0.750–0.976). Participants who reported chest pain (OR, 1.750, 95% CI, 1.209–2.533) and dyspnea (OR, 1.446; 95% CI, 1.052–1.988) during infection had greater odds of changes to their menstrual cycle compared with the participants who did not. The association between the COVID-19 and increased prevalence of menstrual cycle irregularity. COVID-19 vaccination is a protective factor in the long term, and participants with chest pain and dyspnea are more likely to develop AUB.
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DOI：
10.1038/s41579-022-00846-2
发表时间：
2023-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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影响因子：
1.1
作者：
Nguyen PN;Nguyen VT
通讯作者：
Nguyen VT
影响因子：
--
作者：
Amer, Ahmed A.;Amer, Samar A.;Alrufaidi, Khaled Masoud;Abd-Elatif, Eman Elsayed;Alafandi, Bana Zuhair;Yousif, Dalia Abdelmonaim;Armi, Nadia Toukah;Alkhalaf, Atheer Abdulaziz;Shah, Jaffer;Ramadan, Mohamed Sh
通讯作者：
Ramadan, Mohamed Sh
影响因子：
7.7
作者：
Sharp GC;Fraser A;Sawyer G;Kountourides G;Easey KE;Ford G;Olszewska Z;Howe LD;Lawlor DA;Alvergne A;Maybin JA
通讯作者：
Maybin JA
影响因子：
5.2
作者：
Phelan N;Behan LA;Owens L
通讯作者：
Owens L