Flow velocity is relatively uniform in the coronary sinusal venous tree: structure-function relation.
Flow velocity is relatively uniform in the coronary sinusal venous tree: structure-function relation.
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冠状窦静脉树中的流速相对均匀：结构-功能关系
DOI：
10.1152/japplphysiol.00295.2016
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Huo Yunlong
中科院分区：
文献类型：
--
作者：
Wu Hao;Kassab Ghassan S;Tan Wenchang;Huo Yunlong
冠状静脉血管的结构和功能与冠状动脉不同，尽管冠状静脉窦介入治疗具有重要意义，但对冠状静脉血管的结构和功能了解甚少。本文旨在对整个冠状窦静脉树进行血流动力学分析，以加深对冠状静脉循环的理解。建立了一个由5个猪心的铸型和组织学数据重建的全冠状窦静脉树的血流动力学模型。在每根血管中测定各种形态和血流动力学参数，并在直径定义的Strahler系统中进行分析。研究结果表明，冠状静脉系统的分支之间的区域保护，导致相对均匀的流速在不同的顺序的静脉树。压力、周向和壁面切应力从最小的小静脉向-5阶血管（80.4 ± 39.1 µm）突然降低，但向冠状窦显示出更适度的变化。结果表明，5级血管表示从微静脉床到透壁子网的血流动力学过渡。与遵循最小能量假设的冠状动脉树相反，冠状窦静脉系统遵循有效静脉回流的面积保持规则，即，达芬奇的规则。形态学和血流动力学模型作为生理参考状态，通过静脉途径测试各种治疗原理。
新&值得注意
建立了猪心冠状窦静脉树的血流动力学模型。一个关键的发现是，冠状窦静脉系统符合有效静脉回流的面积保留规则，而冠状动脉树遵守最小能量假设。该模型还可以作为生理参考状态，以测试通过静脉途径的各种治疗原理。
The structure and function of coronary venous vessels are different from those of coronary arteries and are much less understood despite the therapeutic significance of coronary sinus interventions. Here we aimed to perform a hemodynamic analysis in the entire coronary sinusal venous tree, which enhances the understanding of coronary venous circulation. A hemodynamic model was developed in the entire coronary sinusal venous tree reconstructed from casts and histological data of five swine hearts. Various morphometric and hemodynamic parameters were determined in each vessel and analyzed in the diameter-defined Strahler system. The findings demonstrate an area preservation between the branches of the coronary venous system that leads to relatively uniform flow velocity in different orders of the venous tree. Pressure and circumferential and wall shear stresses decreased abruptly from the smallest venules toward vessels of order -5 (80.4 ± 39.1 µm) but showed a more modest change toward the coronary sinus. The results suggest that vessels of order -5 denote a hemodynamic transition from the venular bed to the transmural subnetwork. In contrast with the coronary arterial tree, which obeys the minimum energy hypothesis, the coronary sinusal venous system complies with the area-preserving rule for efficient venous return, i.e., da Vinci's rule. The morphometric and hemodynamic model serves as a physiological reference state to test various therapeutic rationales through the venous route.
NEW & NOTEWORTHY
A hemodynamic model is developed in the entire coronary sinusal venous tree of the swine heart. A key finding is that the coronary sinusal venous system complies with the area preservation rule for efficient venous return while the coronary arterial tree obeys the minimum energy hypothesis. This model can also serve as a physiological reference state to test various therapeutic rationales through the venous route.
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DOI：
10.1152/ajpheart.2001.280.3.h1361
发表时间：
2001-03-01
影响因子：
4.8
作者：
Ido, A;Hasebe, N;Kikuchi, K
通讯作者：
Kikuchi, K
影响因子：
20.1
作者：
B. Zweifach;H. Lipowsky
通讯作者：
B. Zweifach;H. Lipowsky
起搏引起的心力衰竭中左回旋冠状动脉树的重塑。
影响因子：
3.3
作者：
Huo Yunlong;Kassab Ghassan S
通讯作者：
Kassab Ghassan S
影响因子：
--
作者：
FRONEK, K;ZWEIFACH, BW
通讯作者：
ZWEIFACH, BW
影响因子：
24
作者：
Banai, Shmuel;Ben Muvhar, Shmuel;Keren, Gad
通讯作者：
Keren, Gad