Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application
Circular RNAs in chemotherapy resistance of lung cancer and their potential therapeutic application
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环状RNA在肺癌化疗耐药中的作用及其潜在的治疗应用
DOI：
10.1002/iub.2624
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发表时间：
2022-05
期刊：
影响因子：
4.6
通讯作者：
Weichao Sun
中科院分区：
文献类型：
--
作者：
Qian Yi;Jianguo Feng;Yi Liao;Weichao Sun
肺癌是世界范围内发病率和死亡率最高的恶性肿瘤之一，约占总癌症诊断的13%。目前，使用抗癌药物仍然是肺癌的主要治疗方法。但随着治疗的进展，癌细胞会逐渐对这些药物产生耐药性。化疗药物耐药的分子机制尚不清楚。circRNA是新近发现的具有共价闭合环状结构的非编码RNA分子。先前的研究表明，circRNA与包括肺癌在内的各种癌症的肿瘤发生和进展相关。近年来，越来越多的研究表明，circRNA可能通过不同的机制参与肺癌细胞的耐药性。本文就circRNA在肺癌化疗耐药调控中的作用及其机制进行综述，并探讨其在肺癌诊断、预后和治疗中的应用前景。
Lung cancer is one of the high malignancy-related incidence and mortality worldwide, accounting for about 13% of total cancer diagnoses. Currently, the use of anti-cancer agents is still the main therapeutic method for lung cancer. However, cancer cells will gradually show resistance to these drugs with the progress of treatment. And the molecular mechanisms underlying chemotherapy agents resistance remain unclear. circRNAs are newly identified noncoding RNAs molecules with covalently closed circular structures. Previous studies have shown that circRNAs are associated with tumorigenesis and progression of various cancers, including lung cancer. Recently, growing reports have suggested that circRNAs could contribute to drug resistance of lung cancer cell through different mechanisms. Therefore, in this review, we summarized the functions and underlying mechanisms of circRNAs in regulating chemoresistance of lung cancer and discussed their potential applications for diagnosis, prognosis, and treatment of lung cancer.
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