Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy.
Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy.
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DOI：
10.1007/978-3-319-74470-4_4
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发表时间：
2018
影响因子：
--
通讯作者：
Mishra PK
中科院分区：
文献类型：
--
作者：
Nandi SS;Mishra PK
糖尿病(DM)是一种多因素疾病，通常被诊断为高血糖水平，其患病率在世界上正在迅速上升。糖尿病与包括心肌病在内的多器官功能障碍的相关性使其成为发病率和死亡率的主要原因。糖尿病有两种主要类型：1型糖尿病(T1D)和2型糖尿病(T2D)。T1D是通过血液中胰岛素水平降低和血糖水平高来诊断的。它是由胰岛β细胞破坏/丢失引起的，主要见于青少年(青少年糖尿病)。通过血液中胰岛素和葡萄糖水平的升高来诊断T2D。它是由于胰岛素受体功能障碍引起的，多见于成人(成人DM)。T1D和T2D都会损害心肌功能，这被称为糖尿病心肌病。我们和其他人已经报道了miRNAs，一类新的微小的非编码调控RNA，在糖尿病心脏中差异表达，它们与糖尿病心肌病有关。在这里，我们阐述了miRNA的生物发生，miRNA如何调控基因，不同miRNAs的心肌保护作用，包括存在于外切体中的miRNAs，miRNA改善糖尿病心肌病的潜在分子机制，以及miRNA作为青少年和成人糖尿病心肌病潜在治疗靶点的作用。
Prevalence of diabetes mellitus (DM), a multifactorial disease often diagnosed with high blood glucose levels, is rapidly increasing in the world. Association of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D) and type 2 DM (T2D). T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood. It is caused due to pancreatic beta cell destruction/loss, and mostly found in juveniles (juvenile DM). T2D is diagnosed by increased levels of insulin and glucose in the blood. It is caused due to insulin receptor dysfunction, and mostly found in the adults (adult DM). Both T1D and T2D impair cardiac muscle function, which is referred to as diabetic cardiomyopathy. We and others have reported that miRNAs, a novel class of tiny non-coding regulatory RNAs, are differentially expressed in the diabetic heart and they contribute to diabetic cardiomyopathy. Here, we elaborated the biogenesis of miRNA, how miRNA regulates a gene, cardioprotective roles of different miRNAs including miRNAs present in exosomes, underlying molecular mechanisms by which miRNA ameliorates diabetic cardiomyopathy, and the role of miRNA as a potential therapeutic target for juvenile and adult diabetic cardiomyopathy.
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影响因子：
7.7
作者：
Bugger H;Boudina S;Hu XX;Tuinei J;Zaha VG;Theobald HA;Yun UJ;McQueen AP;Wayment B;Litwin SE;Abel ED
通讯作者：
Abel ED
DOI：
10.2147/dmso.s30968
发表时间：
2013
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
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通讯作者：
Mishra PK
影响因子：
39.3
作者：
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通讯作者：
Cosentino, Francesco
DOI：
10.1016/j.bbalip.2016.01.010
发表时间：
2016-12-01
影响因子：
4.8
作者：
Caporali, Andrea;Miscianinov, Vladislav;Emanueli, Costanza
通讯作者：
Emanueli, Costanza
影响因子：
3.7
作者：
Brás-Rosário L;Matsuda A;Pinheiro AI;Gardner R;Lopes T;Amaral A;Gama-Carvalho M
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