Discovery of novel small RNAs in the quest to unravel genome complexity.

Discovery of novel small RNAs in the quest to unravel genome complexity.
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发现新型小 RNA 来解开基因组的复杂性。

DOI:
10.1042/bst20120347
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发表时间:
2013
影响因子:
3.9
通讯作者:
Hall AE
Hall AE
中科院分区:
生物学3区
文献类型:
--
作者:
Hall AE

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细胞内不同的RNA群体,或‘RNAome’,形成了一个复杂的、不可或缺的基因调节层。特别是,小的非编码RNA,如microRNAs,已经被证明调控着哺乳动物表达的多达一半的基因。最近从tRNAs、snoRNAs和Y RNAs衍生出的新的小RNA的发现,以及可以减少这些分子的序列偏差的技术的发展,正在慢慢地帮助我们揭开基因组的秘密。
The different RNA populations within the cell, or the ‘RNAome’, form a complex and integral layer of gene regulation. In particular, small non-coding RNAs such as microRNAs have been shown to regulate as much as half of all genes expressed in mammals. The recent discovery of novel small RNAs derived from tRNAs, snoRNAs and Y RNAs, as well as the development of techniques that can reduce sequencing bias of these molecules, is slowly helping us to unveil the secrets of the genome.
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