Evolutionary patterns and selective pressures of odorant/pheromone receptor gene families in teleost fishes.
Evolutionary patterns and selective pressures of odorant/pheromone receptor gene families in teleost fishes.
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DOI：
10.1371/journal.pone.0004083
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发表时间：
2008
期刊：
影响因子：
3.7
通讯作者：
Nishida, Mutsumi
中科院分区：
文献类型：
--
作者：
Hashiguchi, Yasuyuki;Furuta, Yoshimi;Nishida, Mutsumi
硬骨鱼没有犁鼻器(VNO)，它们的犁鼻器受体(V1Rs，V2Rs)表达在主嗅觉上皮(MOE)，气味受体(ORs)和示踪胺相关受体(TAARs)也是如此。在这项研究中，为了深入了解硬骨鱼中四个化学感觉受体家族之间的功能差异，我们研究了斑马鱼、青鱼、刺背鱼、河豚和斑点绿河豚的进化模式。系统发育分析表明，硬骨鱼TAARs中存在许多谱系特异性基因的获得和丢失，而硬骨鱼犁鼻受体中只有少数基因获得和丢失。此外，TAARs的同义和非同义核苷酸替换率(Ka/Ks)有高于ORs和V2Rs的趋势。硬骨鱼TAAR中频繁的基因获得/丢失和高KA/KS表明该家族的受体被用来检测一些物种特有的化学物质，如信息素。相反，硬骨鱼中V1R和V2R家族的保守序列可能意味着这些家族中的受体可以感知硬骨鱼的常见气味，如氨基酸。硬骨ORs的进化模式介于TAARs和犁鼻受体之间。许多硬骨鱼ORs似乎被用于常见的气味，但一些ORs可能已经进化到识别特定血统的气味。
Teleost fishes do not have a vomeronasal organ (VNO), and their vomeronasal receptors (V1Rs, V2Rs) are expressed in the main olfactory epithelium (MOE), as are odorant receptors (ORs) and trace amine-associated receptors (TAARs). In this study, to obtain insights into the functional distinction among the four chemosensory receptor families in teleost fishes, their evolutionary patterns were examined in zebrafish, medaka, stickleback, fugu, and spotted green pufferfish. Phylogenetic analysis revealed that many lineage-specific gene gains and losses occurred in the teleost fish TAARs, whereas only a few gene gains and losses have taken place in the teleost fish vomeronasal receptors. In addition, synonymous and nonsynonymous nucleotide substitution rate ratios (KA/KS) in TAARs tended to be higher than those in ORs and V2Rs. Frequent gene gains/losses and high KA/KS in teleost TAARs suggest that receptors in this family are used for detecting some species-specific chemicals such as pheromones. Conversely, conserved repertoires of V1R and V2R families in teleost fishes may imply that receptors in these families perceive common odorants for teleosts, such as amino acids. Teleost ORs showed intermediate evolutionary pattern between TAARs and vomeronasal receptors. Many teleost ORs seem to be used for common odorants, but some ORs may have evolved to recognize lineage-specific odors.
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影响因子：
10.7
作者：
Grus, Wendy E.;Zhang, Jianzhi
通讯作者：
Zhang, Jianzhi
DOI：
10.1073/pnas.95.20.11987
发表时间：
1998-09-29
影响因子：
11.1
作者：
Cao, YX;Oh, BC;Stryer, L
通讯作者：
Stryer, L
影响因子：
64.8
作者：
Kimoto, H;Haga, S;Touhara, K
通讯作者：
Touhara, K
影响因子：
7
作者：
Saraiva, Luis R.;Korsching, Sigrun I.
通讯作者：
Korsching, Sigrun I.
DOI：
10.1111/j.1748-1716.1994.tb09800.x
发表时间：
1994-10-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
HARA, TJ
通讯作者：
HARA, TJ