G-protein Coupled Estrogen Receptor 1 Expression in Primary Breast Cancers and Its Correlation with Clinicopathological Variables.
G-protein Coupled Estrogen Receptor 1 Expression in Primary Breast Cancers and Its Correlation with Clinicopathological Variables.
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原发性乳腺癌中G蛋白偶联雌激素受体1的表达及其与临床病理变量的相关性
DOI：
10.4048/jbc.2011.14.3.185
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发表时间：
2011-09
影响因子：
2.4
通讯作者：
Tu G
中科院分区：
文献类型：
--
作者：
Luo HJ;Luo P;Yang GL;Peng QL;Liu MR;Tu G
目的 G 蛋白偶联雌激素受体 1 (GPER) 可能在乳腺癌的进展中发挥重要作用，包括内分泌治疗耐药。我们评估了原发性乳腺癌的 GPER。方法采用免疫组织化学法检测423例原发性乳腺癌石蜡包埋组织中GPER的表达情况，并将其表达与临床病理因素相关。结果 GPER在63.8%的标本中表达，在36.6%的肿瘤中与雌激素受体α（ERα）共表达，在62.5%的ERα阴性肿瘤中呈阳性。 GPER的表达与ERα、孕激素受体、HER2状态无关。尽管GPER的表达与淋巴结状态显着负相关（p=0.045），但未发现GPER表达与其他临床病理变量（年龄、月经状态、肿瘤大小、分期、组织学分级、诺丁汉预后指数或病理类型）之间存在相关性。结论 GPER和ERα在原发性乳腺癌中表现出独立的表达分布模式。为了证实研究，需要长期随访和更明确的 ER 分子表型。
Purpose G-protein coupled estrogen receptor 1 (GPER) probably play important roles in the progression of breast cancer including endocrine therapeutic resistance. We evaluated GPER in primary breast cancers. Methods Immunohistochemistry was used to detect GPER in paraffin-embedded tissues of primary breast cancers from 423 patients and GPER expression was correlated with clinicopathological factors. Results GPER was expressed in 63.8% of specimens, coexpressed with estrogen receptor alpha (ERα) in 36.6% of tumors and was positive in 62.5% of the ERα-negative tumors. The expression of GPER had no relationship with the status of ERα, progesterone receptor and HER2. Although the expression of GPER was significantly inversely related with nodal status (p=0.045), no correlation between GPER expression and other clinicopathological variables (age, menstruation status, tumor size, stage, histologic grade, Nottingham Prognostic Index or pathological type) was found. Conclusion GPER and ERα exhibited independent expression pattern of distribution in primary breast cancers. A long-term follow-up and a more definite molecular phenotype for ER are necessary in confirming studies.
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影响因子：
3.8
作者：
Arias-Pulido, Hugo;Royce, Melanie;Gong, Yun;Joste, Nancy;Lomo, Lesley;Lee, Sang-Joon;Chaher, Nabila;Verschraegen, Claire;Lara, Juanita;Prossnitz, Eric R.;Cristofanilli, Massimo
通讯作者：
Cristofanilli, Massimo
影响因子：
--
作者：
Filardo, EJ;Quinn, JA;Bland, KI
通讯作者：
Bland, KI
影响因子：
11.2
作者：
Chen, Jin-Qiang;Russo, Jose
通讯作者：
Russo, Jose
影响因子：
10.4
作者：
Lapensee EW;Tuttle TR;Fox SR;Ben-Jonathan N
通讯作者：
Ben-Jonathan N
影响因子：
3.4
作者：
Leake, R;Barnes, D;Walker, R
通讯作者：
Walker, R