Variations in the FTO gene are associated with severe obesity in the Japanese.
Variations in the FTO gene are associated with severe obesity in the Japanese.
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DOI：
10.1007/s10038-008-0283-1
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发表时间：
2008
影响因子：
3.5
通讯作者：
Nakamura Y
中科院分区：
文献类型：
--
作者：
Hotta K;Nakata Y;Matsuo T;Kamohara S;Kotani K;Komatsu R;Itoh N;Mineo I;Wada J;Masuzaki H;Yoneda M;Nakajima A;Miyazaki S;Tokunaga K;Kawamoto M;Funahashi T;Hamaguchi K;Yamada K;Hanafusa T;Oikawa S;Yoshimatsu H;Nakao K;Sakata T;Matsuzawa Y;Tanaka K;Kamatani N;Nakamura Y
Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22–1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese. The online version of this article (doi:10.1007/s10038-008-0283-1) contains supplementary material, which is available to authorized users.
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影响因子：
3.5
作者：
Yanagiya, Takahiro;Tanabe, Atsushi;Hotta, Kikuko
通讯作者：
Hotta, Kikuko
影响因子：
9.8
作者：
Takei, T;Iida, A;Nakamura, Y
通讯作者：
Nakamura, Y
DOI：
10.1126/science.1151710
发表时间：
2007-11-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gerken T;Girard CA;Tung YC;Webby CJ;Saudek V;Hewitson KS;Yeo GS;McDonough MA;Cunliffe S;McNeill LA;Galvanovskis J;Rorsman P;Robins P;Prieur X;Coll AP;Ma M;Jovanovic Z;Farooqi IS;Sedgwick B;Barroso I;Lindahl T;Ponting CP;Ashcroft FM;O'Rahilly S;Schofield CJ
通讯作者：
Schofield CJ
影响因子：
56.9
作者：
Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
7.7
作者：
Mori, Shintaro;Tanaka, Yasushi;Maeda, Shiro
通讯作者：
Maeda, Shiro