Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources.
Bioengineering human vascular networks: trends and directions in endothelial and perivascular cell sources.
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DOI：
10.1007/s00018-018-2939-0
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Melero-Martin JM
中科院分区：
文献类型：
--
作者：
Wang K;Lin RZ;Melero-Martin JM
组织工程学在再生医学中有着巨大的前景。然而，组织工程领域面临着无数的困难。一个主要的挑战是必须将血管网络整合到生物工程结构中，以实现包括足够的氧合、营养输送和清除废物在内的生理功能。在过去的二十年里，我们在生物工程人类特有的血管网络方面的集体努力取得了显着的进展。研究包括体外和体内研究，多种方法都发现了不同程度的成功。然而，大多数生物工程人类血管网络的方法的共同点是协同使用1)内皮细胞(ECs)-用于连接血管结构管腔的细胞；2)血管周围细胞-通常用于支持EC的功能并为网络提供血管周围的稳定性。在这里，我们重点介绍了过去二十年来血管网络生物工程研究中各种细胞源的使用趋势。为此，我们全面审查了MEDLINE数据库截至2018年的所有生命科学和生物医学出版物。重点放在明确使用人类内皮细胞并与生物工程血管网络特别相关的选择性研究上。为了便于分析，所有的论文都按发表年份进行了分层，然后根据它们对EC和血管周围细胞类型的使用情况进行分析。这项研究提供了一个关于每种可选细胞来源如何在该领域中使用的说明性讨论。我们的目的是揭示趋势，并就细胞来源方面的血管网络生物工程的发展轨迹提供新的见解。
Tissue engineering holds great promise in regenerative medicine. However, the field of tissue engineering faces a myriad of difficulties. A major challenge is the necessity to integrate vascular networks into bioengineered constructs to enable physiological functions including adequate oxygenation, nutrient delivery, and removal of waste products. The last two decades have seen remarkable progress in our collective effort to bioengineer human-specific vascular networks. Studies have included both in vitro and in vivo investigations and multiple methodologies have found varying degrees of success. What most approaches to bioengineer human vascular networks have in common, however, is the synergistic use of both 1) endothelial cells (ECs) - the cells used to line the lumen of the vascular structures; and 2) perivascular cells - usually used to support EC function and provide perivascular stability to the networks. Here, we have highlighted trends in the use of various cellular sources over the last two decades of vascular network bioengineering research. To this end, we comprehensively reviewed all life science and biomedical publications available at the MEDLINE database up to 2018. Emphasis was put on selective studies that definitively used human ECs and were specifically related to bioengineering vascular networks. To facilitate this analysis, all papers were stratified by publication year and then analyzed according to their use of EC and perivascular cell types. This study provides an illustrating discussion on how each alternative source of cells has come to be used in the field. Our intention was to reveal trends and to provide new insights into the trajectory of vascular network bioengineering with regard to cellular sources.
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