Fish Cytolysins in All Their Complexity.
Fish Cytolysins in All Their Complexity.
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DOI：
10.3390/toxins13120877
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发表时间：
2021-12-09
期刊：
影响因子：
4.2
通讯作者：
Figueiredo SG
中科院分区：
文献类型：
--
作者：
Campos FV;Fiorotti HB;Coitinho JB;Figueiredo SG
蝎子状鱼类毒化时观察到的大多数影响可以通过其毒液中存在的细胞溶血素复制。鱼类细胞溶蛋白是一类多功能蛋白，具有致死、细胞溶解、心血管、炎症、伤害性和神经肌肉等多种活性，是一类新的蛋白毒素。这些大的蛋白质(MW150-320 kDa)由两个不同的亚基组成，分别称为α和β，每个亚基约有700个氨基酸残基，通常以低聚形式活跃。不同鱼种的细胞溶血素初级序列具有高度的相似性。这表明这些分子具有相似的作用机制，至少在细胞溶解活性方面，已被证明涉及孔的形成。尽管鱼毒的其余成分具有有趣的生物活性，但鱼类细胞溶血素因其多功能性质和自身复制主要毒液事件的能力而脱颖而出。多年来，关于鱼类细胞溶血素的知识已经积累了相当多，尽管仍有许多有待揭开面纱。本文对鱼类细胞溶血素的生化和药理活性进行了整理和比较，并对其结构、活性、作用机制和未来的展望进行了综述。
The majority of the effects observed upon envenomation by scorpaenoid fish species can be reproduced by the cytolysins present in their venoms. Fish cytolysins are multifunctional proteins that elicit lethal, cytolytic, cardiovascular, inflammatory, nociceptive, and neuromuscular activities, representing a novel class of protein toxins. These large proteins (MW 150–320 kDa) are composed by two different subunits, termed α and β, with about 700 amino acid residues each, being usually active in oligomeric form. There is a high degree of similarity between the primary sequences of cytolysins from different fish species. This suggests these molecules share similar mechanisms of action, which, at least regarding the cytolytic activity, has been proved to involve pore formation. Although the remaining components of fish venoms have interesting biological activities, fish cytolysins stand out because of their multifunctional nature and their ability to reproduce the main events of envenomation on their own. Considerable knowledge about fish cytolysins has been accumulated over the years, although there remains much to be unveiled. In this review, we compiled and compared the current information on the biochemical aspects and pharmacological activities of fish cytolysins, going over their structures, activities, mechanisms of action, and perspectives for the future.
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影响因子：
3.4
作者：
Colasante, C;Meunier, FA;Molgo, J
通讯作者：
Molgo, J
影响因子：
4.8
作者：
Ghadessy, FJ;Chen, DS;Yuen, R
通讯作者：
Yuen, R
影响因子：
3.3
作者：
Borges, Marcia H.;Andrich, Filipe;Figueiredo, Suely G.
通讯作者：
Figueiredo, Suely G.
DOI：
10.1073/pnas.1507622112
发表时间：
2015-12-15
影响因子：
11.1
作者：
Ellisdon, Andrew M.;Reboul, Cyril F.;McGowan, Sheena
通讯作者：
McGowan, Sheena
影响因子：
2.8
作者：
CHHATWAL, I;DREYER, F
通讯作者：
DREYER, F