Surface-based information mapping reveals crossmodal vision-action representations in human parietal and occipitotemporal cortex.
Surface-based information mapping reveals crossmodal vision-action representations in human parietal and occipitotemporal cortex.
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DOI：
10.1152/jn.00326.2010
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发表时间：
2010-08
影响因子：
2.5
通讯作者：
Downing PE
中科院分区：
文献类型：
--
作者：
Oosterhof NN;Wiggett AJ;Diedrichsen J;Tipper SP;Downing PE
许多证据表明，对行为的感性和运动性表征之间存在紧密联系。许多演示展示了一个动作的视觉感知如何在观察者的运动系统中参与到相容的活动中。这在非传递性动作(例如，在无意识姿势模仿的情况下)和传递性动作(例如，抓住物体的情况下)都可以看到。虽然在猕猴身上发现的“镜像神经元”启发了对人类动作行为中这些过程的解释，但人类大脑中类似地形成动作的跨模式视觉/运动表征的区域的证据仍然不完整。为了解决这一问题，在本研究中，参与者在接受功能磁共振扫描的同时进行并观察手部动作。我们采用了数据驱动的方法，使用多体素模式分析(MVPA)分类器应用全脑信息映射，对皮质表面的重建表示执行。目的是确定局部体素活动模式可以区分不同动作的区域，跨越视觉和运动领域。实验1测试的是非传递性、无意义的手部动作，而实验2测试的是物体定向动作(都是右手)。我们对这两个实验的分析显示，在外侧枕颞叶皮质(两侧)和左侧中央后回/前顶叶皮质存在交叉通道活动区域。此外，在实验2中，我们发现了左半球中央后/顶叶区域信息模式的偏向梯度。中央后回携带了更多关于执行动作的效应器的信息(手指和整个手)，而前顶区域则携带了更多关于动作目标的信息(举起和猛击)。综上所述，这些结果为这些动作的视觉和运动方面的共同神经编码提供了证据，并进一步证明了MVPA如何有助于我们对分布式神经表征的本质的理解。
Many lines of evidence point to a tight linkage between the perceptual and motoric representations of actions. Numerous demonstrations show how the visual perception of an action engages compatible activity in the observer's motor system. This is seen for both intransitive actions (e.g., in the case of unconscious postural imitation) and transitive actions (e.g., grasping an object). Although the discovery of “mirror neurons” in macaques has inspired explanations of these processes in human action behaviors, the evidence for areas in the human brain that similarly form a crossmodal visual/motor representation of actions remains incomplete. To address this, in the present study, participants performed and observed hand actions while being scanned with functional MRI. We took a data-driven approach by applying whole-brain information mapping using a multivoxel pattern analysis (MVPA) classifier, performed on reconstructed representations of the cortical surface. The aim was to identify regions in which local voxelwise patterns of activity can distinguish among different actions, across the visual and motor domains. Experiment 1 tested intransitive, meaningless hand movements, whereas experiment 2 tested object-directed actions (all right-handed). Our analyses of both experiments revealed crossmodal action regions in the lateral occipitotemporal cortex (bilaterally) and in the left postcentral gyrus/anterior parietal cortex. Furthermore, in experiment 2 we identified a gradient of bias in the patterns of information in the left hemisphere postcentral/parietal region. The postcentral gyrus carried more information about the effectors used to carry out the action (fingers vs. whole hand), whereas anterior parietal regions carried more information about the goal of the action (lift vs. punch). Taken together, these results provide evidence for common neural coding in these areas of the visual and motor aspects of actions, and demonstrate further how MVPA can contribute to our understanding of the nature of distributed neural representations.
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DOI：
10.1093/cercor/bhn181
发表时间：
2009-06
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Gazzola V;Keysers C
通讯作者：
Keysers C
影响因子：
2
作者：
Candidi, Matteo;Urgesi, Cosimo;Aglioti, Salvatore M.
通讯作者：
Aglioti, Salvatore M.
影响因子：
5.7
作者：
Cunnington, R;Windischberger, C;Moser, E
通讯作者：
Moser, E
影响因子：
9.2
作者：
Dinstein, Ilan;Thomas, Cibu;Heeger, David J.
通讯作者：
Heeger, David J.
影响因子：
1.8
作者：
Grill-Spector, K;Malach, R
通讯作者：
Malach, R