Dopamine release during human emotional processing.
Dopamine release during human emotional processing.
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DOI：
10.1016/j.neuroimage.2009.06.008
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发表时间：
2009-10-01
期刊：
影响因子：
5.7
通讯作者：
Alpert, Nathaniel M.
中科院分区：
文献类型：
--
作者：
Badgaiyan, Rajendra D.;Fischman, Alan J.;Alpert, Nathaniel M.
多巴胺神经传递在人类情绪处理中的参与尚不清楚，但动物研究表明，它对恐惧反应的处理至关重要。在这个实验中，我们研究了多巴胺能参与人类情绪的处理。我们使用了一种新的动态分子成像技术来检测和映射在呈现情绪刺激时释放的多巴胺。该技术利用内源性释放的多巴胺和其配体之间的竞争受体占用，并涉及动态体素的速度，其中多巴胺受体配体（18F-Fallypride）在情绪处理过程中从受体位点被取代的测量。速率的增加表明多巴胺释放。我们发现，左杏仁核，左内侧颞叶（MTL）和左额下回的配体置换率显着增加。这些结果提供了多巴胺能调节人类情绪处理的第一个直接证据，并表明调制发生在多个层次的处理。这一发现表明，人类情绪的神经认知模型应考虑多巴胺能效应，并且有必要研究多巴胺能系统的操纵是否可以作为治疗情绪处理受损的疾病的替代策略。
Involvement of dopamine neurotransmission in human emotional processing is unclear but animal studies have indicated that it is critical for processing of fear response. In this experiment we examined dopaminergic involvement in the processing of human emotions. We used a novel dynamic molecular imaging technique to detect and map dopamine released during presentation of emotional stimuli. The technique exploited the competition between endogenously released dopamine and its ligand for receptor occupancy and involved dynamic voxel-wise measurement of the rate at which a dopamine receptor ligand (18F-Fallypride) was displaced from receptor sites during emotional processing. An increase in the rate indicated dopamine release. We found that the rate of ligand displacement increased significantly in the left amygdala, left medial temporal lobe (MTL) and left inferior frontal gyrus. The results provide the first direct evidence of dopaminergic modulation of human emotional processing and suggest that the modulation occurs at multiple levels of processing. This finding indicates that the neurocognitive models of human emotion should take into account dopaminergic effects, and that, there is a need to investigate whether manipulation of the dopaminergic system could be an alternate strategy for treatment of conditions in which emotional processing is impaired.
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