The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study.
The effect of rural-to-urban migration on renal function in an Indian population: cross-sectional data from the Hyderabad arm of the Indian Migration Study.
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DOI：
10.1186/1471-2369-14-240
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发表时间：
2013-10-31
期刊：
影响因子：
2.3
通讯作者：
Ben-Shlomo Y
中科院分区：
文献类型：
--
作者：
Bailey PK;Tomson CR;Kinra S;Ebrahim S;Radhakrishna KV;Kuper H;Nitsch D;Ben-Shlomo Y
城市移民与印度移民中高血压、肥胖和糖尿病风险增加有关。本研究评估了印度移民研究海得拉巴组的国内移民与肾功能之间的关系。我们评估了841名受试者;城市非移民（n = 158），城市移民（n = 424）和农村非移民（n = 259）。DXA扫描确定肌肉质量。我们得出了城市移民和农村非移民的城市寿命年。使用多变量线性回归分析城市生命年三分位数与4变量MDRD eGFR之间的相关性，使用Stata 11。城市非移民和城市移民的平均eGFR低于农村非移民。由于农村非流动人口的eGFR呈负偏态分布，农村非流动人口中CKD 3-5的患病率（5.0%）高于城市非流动人口（2.5%）。随着城市生活年的增加，eGFR下降（p = 0.008），但没有明显的剂量反应效应。调整肌肉质量后，相关性减弱，趋势与偶然性一致（p = 0.08）。进一步调整血管风险因素，在很小程度上削弱了这种关联（p = 0.11）。农村地区eGFR降低的高患病率需要进一步研究。城市化与eGFR降低相关。这种关联似乎主要是由于较高的肌肉质量，不良血管疾病风险因素的贡献很小。
Urban migration is associated with an increased risk of hypertension, obesity and diabetes in Indian migrants. This study assessed the relationship between internal migration and renal function in the Hyderabad arm of the Indian Migration Study. We assessed 841 subjects; urban non-migrants (n = 158), urban migrants (n = 424) and rural non-migrants (n = 259). Muscle mass was ascertained from DXA scanning. We derived urban life years for urban migrants and rural non-migrants. Multivariable linear regression was used to examine the association between tertiles of urban life years and 4-variable MDRD eGFR using Stata 11. Mean eGFR was lower in urban non-migrants and urban migrants compared to rural non-migrants. The prevalence of CKD 3-5 was higher in the rural non-migrant population (5.0%) than in the urban non-migrant populations (2.5%) due to a negatively skewed distribution of eGFR in rural non-migrants. As urban life years increased, eGFR declined (p = 0.008) though there was no obvious dose response effect. After adjustment for muscle mass, the association was attenuated and the trend was consistent with chance (p = 0.08). Further adjustment for vascular risk factors weakened the association to a small degree (p = 0.11). The high prevalence of reduced eGFR in rural areas requires further research. Urbanization was associated with reduced eGFR. This association appears mostly to be due to higher muscle mass with a small contribution from adverse vascular disease risk factors.
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影响因子：
2.3
作者：
Rajapurkar MM;John GT;Kirpalani AL;Abraham G;Agarwal SK;Almeida AF;Gang S;Gupta A;Modi G;Pahari D;Pisharody R;Prakash J;Raman A;Rana DS;Sharma RK;Sahoo RN;Sakhuja V;Tatapudi RR;Jha V
通讯作者：
Jha V
影响因子：
4.2
作者：
Bandara, J. M. R. S.;Senevirathna, D. M. A. N.;Rajapaksha, K. H.
通讯作者：
Rajapaksha, K. H.
影响因子：
2.3
作者：
Bailey, Phillippa K.;Tomson, Charles R. V.;Ben-Shlomo, Yoav
通讯作者：
Ben-Shlomo, Yoav
影响因子：
3
作者：
Mittal, S;Kher, V;Arora, P
通讯作者：
Arora, P
影响因子：
3.5
作者：
BURDEN, AC;MCNALLY, PG;WALLS, J
通讯作者：
WALLS, J