Glucose intolerance and gestational diabetes risk in relation to sleep duration and snoring during pregnancy: a pilot study.
Glucose intolerance and gestational diabetes risk in relation to sleep duration and snoring during pregnancy: a pilot study.
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DOI：
10.1186/1472-6874-10-17
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发表时间：
2010-05-14
期刊：
影响因子：
--
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Qiu C;Enquobahrie D;Frederick IO;Abetew D;Williams MA
睡眠不足和睡眠质量差被认为是现代社会的地方病，与肥胖、糖耐量受损和糖尿病有关。然而，人们对妊娠期睡眠不足和睡眠质量差对糖耐量和妊娠期糖尿病的影响知之甚少。在怀孕早期对1，290名妇女进行了访谈。我们收集了关于怀孕早期睡眠时间和打鼾的信息。妊娠期糖尿病（GDM）的筛查和诊断检测结果摘自病历。广义线性模型拟合得出GDM的相对危险度（RR）和95%置信区间（95%CI）与睡眠时间和打鼾，分别。在调整母亲年龄和种族/民族后，与每晚睡眠9小时的女性相比，睡眠≤ 4小时的女性GDM风险增加（RR = 5.56; 95%CI 1.31-23.69）。瘦女性（<25 kg/m2）的相应RR为3.23（95% CI 0.34-30.41），超重女性（≥ 25 kg/m2）的相应RR为9.83（95% CI 1.12-86.32）。总体而言，打鼾与GDM风险增加1.86倍相关（RR = 1.86; 95%CI 0.88-3.94）。在打鼾的超重女性中，GDM的风险尤其高。与不打鼾的瘦女性相比，那些超重和打鼾的女性患GDM的风险增加了6.9倍（95%CI 2.87-16.6）。这些初步研究结果表明睡眠时间短和打鼾与葡萄糖耐受不良和GDM有关。虽然与男性和非妊娠女性的研究一致，但需要更大规模的研究，包括睡眠时间，质量和呼吸暂停的客观测量，以获得对观察到的相关性的更精确估计。
Insufficient sleep and poor sleep quality, considered endemic in modern society, are associated with obesity, impaired glucose tolerance and diabetes. Little, however, is known about the consequences of insufficient sleep and poor sleep quality during pregnancy on glucose tolerance and gestational diabetes. A cohort of 1,290 women was interviewed during early pregnancy. We collected information about sleep duration and snoring during early pregnancy. Results from screening and diagnostic testing for gestational diabetes mellitus (GDM) were abstracted from medical records. Generalized linear models were fitted to derive relative risk (RR) and 95% confidence intervals (95% CIs) of GDM associated with sleep duration and snoring, respectively. After adjusting for maternal age and race/ethnicity, GDM risk was increased among women sleeping ≤ 4 hours compared with those sleeping 9 hours per night (RR = 5.56; 95% CI 1.31-23.69). The corresponding RR for lean women (<25 kg/m2) was 3.23 (95% CI 0.34-30.41) and 9.83 (95% CI 1.12-86.32) for overweight women (≥ 25 kg/m2). Overall, snoring was associated with a 1.86-fold increased risk of GDM (RR = 1.86; 95% CI 0.88-3.94). The risk of GDM was particularly elevated among overweight women who snored. Compared with lean women who did not snore, those who were overweight and snored had a 6.9-fold increased risk of GDM (95% CI 2.87-16.6). These preliminary findings suggest associations of short sleep duration and snoring with glucose intolerance and GDM. Though consistent with studies of men and non-pregnant women, larger studies that include objective measures of sleep duration, quality and apnea are needed to obtain more precise estimates of observed associations.
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