Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study.
Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study.
复制标题
DOI：
10.1371/journal.pone.0198969
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Morse LR
中科院分区：
文献类型：
--
作者：
Park AJ;Battaglino RA;Nguyen NMH;Morse LR
瘦素是一种脂肪肌因子，通过神经内分泌反馈回路调节食欲和能量消耗。在脊髓损伤人群中瘦素水平与BMI呈正相关，与未受伤的对照组相比，脊髓损伤个体中的瘦素水平更高。瘦素在多种组织中产生，包括脂肪、骨骼和骨骼肌，并且是老年人久坐行为的假定生物标志物。我们评估了205例慢性脊髓损伤患者的身体成分瘦素、脂联素和IL-6水平。我们没有发现年龄、损伤持续时间、损伤程度、损伤完整性或行走状态与瘦素之间的相关性。在SCI患者中，瘦体重和瘦素之间存在显著的正相关，而与脂肪无关。调整身体成分后，瘦素水平与IL-6呈正相关，与脂联素水平呈负相关。当考虑到SCI和肌肉减少性肥胖的男性时，只有脂肪量与瘦素呈正相关。我们没有发现IL-6，脂联素，或瘦体重和瘦素在肌肉减少性肥胖组之间的关联。我们的研究结果表明，瘦体重是一个公认的，但实质性的，循环瘦素的来源。此外，SCI相关的肌肉减少性肥胖可能导致脂肪-肌因子代谢失调，具有局部和全身生理效应。
Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.
登录
查看更多内容
影响因子：
2.2
作者：
Gorgey, A. S.;Dudley, G. A.
通讯作者：
Dudley, G. A.
影响因子：
6.2
作者：
Doherty, Ashley L.;Battaglino, Ricardo A.;Morse, Leslie R.
通讯作者：
Morse, Leslie R.
影响因子：
3.7
作者：
Arounleut P;Bowser M;Upadhyay S;Shi XM;Fulzele S;Johnson MH;Stranahan AM;Hill WD;Isales CM;Hamrick MW
通讯作者：
Hamrick MW
影响因子：
3.7
作者：
Bigford, Gregory E.;Bracchi-Ricard, Valerie C.;Bethea, John R.
通讯作者：
Bethea, John R.
DOI：
10.1111/j.1749-6632.2002.tb04293.x
发表时间：
2002-01-01
期刊：
LIPIDS AND INSULIN RESISTANCE: THE ROLE OF FATTY ACID METABOLISM AND FUEL PARTITIONING
影响因子：
--
作者：
Jéquier, E
通讯作者：
Jéquier, E