The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility.
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility.
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DOI：
10.1016/j.fertnstert.2013.01.111
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发表时间：
2013-03-15
影响因子：
6.7
通讯作者：
Lamb DJ
中科院分区：
文献类型：
--
作者：
Kovac JR;Pastuszak AW;Lamb DJ
尽管事实上，男性因素约占所有不孕症的50%，但其起源的机制尚不清楚。目前，临床医生主要依靠精液分析来预测男性生殖潜力和治疗成功率。即使进行侵入性手术，男性不育的原因往往仍然难以捉摸。最近，新技术的出现刺激了对新的男性不育生物标志物的搜索，并且检测不育男性特有的基因、蛋白质或代谢物具有很大的希望。一个具有成本效益的，非侵入性的和准确的生物标志物可以确定诊断男性不育的概念是诱人的。本文综述了发现新型生物标志物的各种方法及其研究结果沿着。特别注意的是在遗传学，蛋白质组学和代谢组学领域的最新进展。
Despite the fact that male factors contribute to approximately 50% of all infertility, the mechanisms underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses to predict male reproductive potential and chart treatment success. Even when invasive procedures are performed, the causes of male infertility frequently remain elusive. Recently, the advent of new technologies has spurred the search for novel male infertility biomarkers, and the detection of genes, proteins or metabolites unique to the infertile male holds much promise. The concept that a cost-effective, non-invasive and accurate set of biomarkers can be identified to diagnose male infertility is tantalizing. This review focuses on the various methodologies employed in the discovery of novel biomarkers along with their findings. Specific attention is paid to recent advances in the fields of genetics, proteomics and metabolomics.
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