Robocasting of Ceramic Fischer-Koch S Scaffolds for Bone Tissue Engineering.
Robocasting of Ceramic Fischer-Koch S Scaffolds for Bone Tissue Engineering.
复制标题
用于骨组织工程的陶瓷Fischer-Koch S支架的机器人。
DOI：
10.3390/jfb14050251
复制
发表时间：
2023-04-30
影响因子：
4.8
通讯作者：
Prawel, David
中科院分区：
文献类型：
--
作者：
Baumer, Vail;Gunn, Erin;Riegle, Valerie;Bailey, Claire;Shonkwiler, Clayton;Prawel, David
关键词：
三周期最小表面（TPMS）由于其相对较高的机械能吸收、平滑互连的多孔结构、可扩展的单位细胞拓扑以及相对较高的单位体积表面积，是骨组织工程支架的有前途的结构。磷酸钙基材料，例如羟基磷灰石和磷酸三钙，由于其生物相容性、生物活性、与骨矿物质的成分相似性、非免疫原性和可调节的生物降解性，是非常受欢迎的支架生物材料。它们的脆性可以通过在 TPMS 拓扑（例如陀螺仪）中进行 3D 打印来部分缓解，陀螺仪已被广泛研究用于骨再生，流行的 3D 打印切片机、建模系统和拓扑优化工具中的存在就证明了这一点。尽管据我们所知，结构和流动模拟已经预测了其他 TPMS 支架（例如 Fischer-Koch S (FKS)）的有前途的特性，但没有人在实验室中探索过骨再生的这些可能性。造成这种情况的原因之一是，FKS 支架的制造（例如通过 3D 打印）面临着缺乏对这种拓扑进行建模和切片以供低成本生物材料打印机使用的算法的挑战。本文介绍了我们开发的一种开源软件算法，用于创建可 3D 打印的 FKS 和陀螺仪支架立方体，其框架可以接受任何连续可微隐函数。我们还报告了我们使用机器人铸造与分层光聚合相结合的低成本方法成功 3D 打印羟基磷灰石 FKS 支架。还介绍了尺寸精度、内部微观结构和孔隙率特征，展示了 3D 打印 TPMS 陶瓷支架用于骨再生的巨大潜力。
Triply Periodic Minimal Surfaces (TPMS) are promising structures for bone tissue engineering scaffolds due to their relatively high mechanical energy absorption, smoothly interconnected porous structure, scalable unit cell topology, and relatively high surface area per volume. Calcium phosphate-based materials, such as hydroxyapatite and tricalcium phosphate, are very popular scaffold biomaterials due to their biocompatibility, bioactivity, compositional similarities to bone mineral, non-immunogenicity, and tunable biodegradation. Their brittle nature can be partially mitigated by 3D printing them in TPMS topologies such as gyroids, which are widely studied for bone regeneration, as evidenced by their presence in popular 3D-printing slicers, modeling systems, and topology optimization tools. Although structural and flow simulations have predicted promising properties of other TPMS scaffolds, such as Fischer–Koch S (FKS), to the best of our knowledge, no one has explored these possibilities for bone regeneration in the laboratory. One reason for this is that fabrication of the FKS scaffolds, such as by 3D printing, is challenged by a lack of algorithms to model and slice this topology for use by low-cost biomaterial printers. This paper presents an open-source software algorithm that we developed to create 3D-printable FKS and gyroid scaffold cubes, with a framework that can accept any continuous differentiable implicit function. We also report on our successful 3D printing of hydroxyapatite FKS scaffolds using a low-cost method that combines robocasting with layer-wise photopolymerization. Dimensional accuracy, internal microstructure, and porosity characteristics are also presented, demonstrating promising potential for the 3D printing of TPMS ceramic scaffolds for bone regeneration.
登录
查看更多内容
影响因子：
6.2
作者：
Amin, Shreyasee;Achenbach, Sara J.;Atkinson, Elizabeth J.;Khosla, Sundeep;Melton, L. Joseph, III
通讯作者：
Melton, L. Joseph, III
影响因子：
8.4
作者：
Abueidda, Diab W.;Elhebeary, Mohamed;Jasiuk, Iwona M.
通讯作者：
Jasiuk, Iwona M.
影响因子：
8.4
作者：
Germain, Loic;Fuentes, Carlos A.;Dupont-Gillain, Christine
通讯作者：
Dupont-Gillain, Christine
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna
影响因子：
7.4
作者：
Gross, Bethany C.;Erkal, Jayda L.;Spence, Dana M.
通讯作者：
Spence, Dana M.