The transmitral pressure-flow velocity relation. Effect of abrupt preload reduction.
The transmitral pressure-flow velocity relation. Effect of abrupt preload reduction.
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传输压力-流速关系。
DOI：
10.1161/01.cir.78.6.1459
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发表时间：
1988
期刊：
影响因子：
37.8
通讯作者：
Ludbrook,PA
中科院分区：
文献类型：
--
作者：
Courtois,M;Vered,Z;Barzilai,B;Ricciotti,NA;Pérez,JE;Ludbrook,PA
虽然最近的动物和临床研究表明，多普勒衍生的指数可能是有用的心室舒张行为的表征，这些指数的前负荷依赖性的血流动力学基础尚未完全阐明。因此，在10只麻醉、闭胸的狗上，通过同时记录左心房和左心室微压测量和经食管多普勒超声心动图，研究了左心房负荷减少对短暂下腔静脉阻塞期间压力-流速关系的影响。下腔静脉球囊闭塞后4 ~ 5次心搏内，左心房负荷降低，左心房v波斜率从21 +/- 4降至13 +/- 4 mm Hg/sec（p <0.001）以及左心房和左心室压力的第一个交叉点从5.6 +/- 1.1 mmHg降至2.9 +/- 1.5 mmHg（P <0.001）。左心房负荷的这种降低导致早期最小左心室压力（从1.0 +/- 0.8到-0.4 +/- 1.2 mm Hg，p <0.001）、最大早期前向压力（即，左心房压力大于左心室压力）跨瓣压力梯度（从2.8 +/-0.8到2.4 +/-0.5mmHg，p小于0.01）;快速充盈压力波的斜率（从44 +/-11到38 +/-10mmHg/sec，p小于0.025）;和反向面积（即，左心室压力大于左心房压力）跨瓣压差（从79 +/- 42到53 +/- 33 mm Hg.msec，p <0.05）。在晚期二尖瓣关闭不全期间，左心房和左心室a波的高度和斜率均下降，导致最大晚期跨瓣压差降低（从1.2 +/- 0.7降至0.9 +/- 0.5 mm Hg，p <0.05）。腔静脉阻塞也改变了多普勒二尖瓣流速分布在早期和晚期阶段的栓塞。E波峰值速度降低（从50 +/- 11到41 +/- 7 cm/sec，p小于0.01），加速度也是如此（从880 +/- 222到757 +/- 258 cm/sec 2，p小于0.025）和减速（从597 +/- 260到429 +/- 197 cm/sec 2，p小于0.025）。A波的峰值速度也下降（从29 +/- 9降至22 +/- 5 cm/sec，p <0.005）。突然下腔静脉闭塞并没有显着改变心率或平均主动脉压。（400字处截断摘要）
Although recent animal and clinical studies suggest that Doppler-derived indexes may be useful for the characterization of ventricular diastolic behavior, the hemodynamic basis for the preload dependency of these indexes has not previously been fully elucidated. Accordingly, effects of reduction of left atrial load on the pressure-flow velocity relation were characterized in 10 anesthetized, closed-chest dogs during transient inferior vena caval occlusion by means of simultaneously recorded left atrial and left ventricular micromanometric pressure measurement and transesophageal Doppler echocardiograms. Within four or five beats after inferior vena caval balloon occlusion, left atrial loading was reduced as evidenced by a decrease in the slope of the left atrial v wave from 21 +/- 4 to 13 +/- 4 mm Hg/sec (p less than 0.001) and by a decrease in the first crossover point of left atrial and left ventricular pressures from 5.6 +/- 1.1 to 2.9 +/- 1.5 mm Hg (p less than 0.001). This decrease in left atrial loading resulted in reductions during early diastole of minimum left ventricular pressure (from 1.0 +/- 0.8 to -0.4 +/- 1.2 mm Hg, p less than 0.001), the maximum early forward (i.e., left atrial pressure greater than left ventricular pressure) transmitral pressure gradient (from 2.8 +/- 0.8 to 2.4 +/- 0.5 mm Hg, p less than 0.01); the slope of the rapid filling pressure wave (from 44 +/- 11 to 38 +/- 10 mm Hg/sec, p less than 0.025); and the area of the reversed (i.e., left ventricular pressure greater than left atrial pressure) transmitral pressure gradient (from 79 +/- 42 to 53 +/- 33 mm Hg.msec, p less than 0.05). During late diastole, both the heights and slopes of the left atrial and left ventricular a waves fell, resulting in a decrease in the maximum late transmitral pressure gradient (from 1.2 +/- 0.7 to 0.9 +/- 0.5 mm Hg, p less than 0.05). Vena caval occlusion also altered Doppler transmitral velocity profiles during both the early and late phases of diastole. Peak velocity of the E wave decreased (from 50 +/- 11 to 41 +/- 7 cm/sec, p less than 0.01) as did acceleration (from 880 +/- 222 to 757 +/- 258 cm/sec2, p less than 0.025) and deceleration (from 597 +/- 260 to 429 +/- 197 cm/sec2, p less than 0.025). Peak velocity of the A wave also fell (from 29 +/- 9 to 22 +/- 5 cm/sec, p less than 0.005). Abrupt inferior vena caval occlusion did not significantly change heart rate or mean aortic pressure.(ABSTRACT TRUNCATED AT 400 WORDS)
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心室舒张的力学。
影响因子：
10.8
作者：
J. Tyberg;Wilbert J. Keon;E. H. Sonnenblick;C. W. Urschel
通讯作者：
C. W. Urschel
DOI：
10.1253/jcj.46.124
发表时间：
1982-01-01
期刊：
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
影响因子：
--
作者：
HORI, M;YELIIN, EL;SONNENBLICK, EH
通讯作者：
SONNENBLICK, EH
影响因子：
15.9
作者：
VANDEWERF, F;MINTEN, J;KESTELOOT, H
通讯作者：
KESTELOOT, H
弹性平衡状态下无搏动离体狗心脏的心室容积
影响因子：
20.1
作者：
G. A. Brecher;H. Kolder;A. D. Horres
通讯作者：
A. D. Horres
扩张型心肌病左心室充盈的脉冲多普勒超声心动图研究。
DOI：
10.1016/0002-9149(86)90258-4
发表时间：
1986
期刊：
The American journal of cardiology
影响因子：
--
作者：
K. Takenaka;A. Dabestani;J. Gardin;Daniel Russell;S. Clark;A. Allfie;W. Henry
通讯作者：
W. Henry