Associations of social environment, socioeconomic position and social mobility with immune response in young adults: the Jerusalem Perinatal Family Follow-Up Study.
Associations of social environment, socioeconomic position and social mobility with immune response in young adults: the Jerusalem Perinatal Family Follow-Up Study.
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社会环境，社会经济地位和社会流动性与年轻人的免疫反应的关联：耶路撒冷围产期家庭随访研究。
DOI：
10.1136/bmjopen-2017-016949
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发表时间：
2017-12-21
期刊：
影响因子：
2.9
通讯作者：
Hochner H
中科院分区：
文献类型：
--
作者：
Lawrence GM;Friedlander Y;Calderon-Margalit R;Enquobahrie DA;Huang JY;Tracy RP;Manor O;Siscovick DS;Hochner H
对巨细胞病毒 (CMV) 的免疫反应会影响成人慢性病。本研究调查了童年和成年社会环境、社会经济地位 (SEP) 和社会流动性与年轻人 CMV 反应的关系。历史前瞻性研究设计。 1974 年至 1976 年间耶路撒冷居民所有 17003 名新生儿的子队列。参与者包括 1319 名在耶路撒冷出生的年轻人，拥有广泛的档案和随访数据，包括儿童期和成年期 SEP 相关因素以及 32 岁时测量的抗 CMV IgG 滴度水平和血清阳性率。主成分分析用于转换两个时间点（儿童期和成年期）的相关社会环境和 SEP 相关变量。成年期）分为反映家庭（例如，兄弟姐妹/孩子的数量、宗教信仰）和社会经济（例如，职业、教育）组成部分的两个主要分数。基于这些组成部分，创建了社会流动变量。线性和泊松回归模型用于研究成分和迁移率与抗 CMV IgG 滴度水平和血清阳性率的关联，并针对混杂因素进行了调整。儿童期或成年期较低水平的家庭和社会经济成分与32岁时较高的抗CMV IgG滴度和血清阳性相关。与具有稳定有利成分的个体相比，稳定的不利家庭和社会经济成分的抗CMV IgG滴度和血清阳性风险较高（家庭：β=3.23，P<0.001；相对风险（RR）=1.21，P<0.001；社会经济：β=2.20，P=0.001；RR=1.14，P=0.01），向下的家庭流动性（β=4.32，P<0.001；RR=1.26，P<0.001）和向上的社会经济流动性（β=1.37，P=0.04；RR=1.19，P<0.001）。在血清阳性个体中，家庭成分和流动性与抗 CMV IgG 滴度水平之间的关联得以维持，而社会经济成分和流动性与抗 CMV IgG 滴度水平之间的关联减弱。我们的研究提供的证据表明，从童年到成年和社会流动积累的低 SEP 可能会损害成年早期的免疫反应。
Immune response to cytomegalovirus (CMV) impacts adult chronic disease. This study investigates associations of childhood and adulthood social environment, socioeconomic position (SEP) and social mobility with CMV response in young adults. Historical prospective study design. Subcohort of all 17 003 births to residents of Jerusalem between 1974 and 1976. Participants included 1319 young adults born in Jerusalem with extensive archival and follow-up data, including childhood and adulthood SEP-related factors and anti-CMV IgG titre levels and seroprevalence measured at age 32. Principal component analysis was used to transform correlated social environment and SEP-related variables at two time points (childhood and adulthood) into two major scores reflecting household (eg, number of siblings/children, religiosity) and socioeconomic (eg, occupation, education) components. Based on these components, social mobility variables were created. Linear and Poisson regression models were used to investigate associations of components and mobility with anti-CMV IgG titre level and seroprevalence, adjusted for confounders. Lower levels of household and socioeconomic components in either childhood or adulthood were associated with higher anti-CMV IgG titre level and seropositivity at age 32. Compared with individuals with stable favourable components, anti-CMV IgG titre level and risk for seropositivity were higher in stable unfavourable household and socioeconomic components (household: β=3.23, P<0.001; relative risk (RR)=1.21, P<0.001; socioeconomic: β=2.20, P=0.001; RR=1.14, P=0.01), downward household mobility (β=4.32, P<0.001; RR=1.26, P<0.001) and upward socioeconomic mobility (β=1.37, P=0.04; RR=1.19, P<0.001). Among seropositive individuals, associations between household components and mobility with anti-CMV IgG titre level were maintained and associations between socioeconomic components and mobility with anti-CMV IgG titre level were attenuated. Our study provides evidence that accumulating low SEP from childhood through adulthood and social mobility may compromise immune response in young adulthood.
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影响因子：
5.1
作者：
Jansen, Michelle A. E.;van den Heuvel, Diana;Moll, Henriette A.
通讯作者：
Moll, Henriette A.
影响因子：
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Susser, Ezra
影响因子：
5.4
作者：
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通讯作者：
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