Effect of socioeconomic status and parents' education at birth on risk of schizophrenia in offspring.
Effect of socioeconomic status and parents' education at birth on risk of schizophrenia in offspring.
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DOI：
10.1007/s00127-008-0439-5
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发表时间：
2009-04
影响因子：
4.4
通讯作者：
Susser, Ezra
中科院分区：
文献类型：
--
作者：
Corcoran, Cheryl;Perrin, Mary;Harlap, Susan;Deutsch, Lisa;Fennig, Shmuel;Manor, Orly;Nahon, Daniella;Kimhy, David;Malaspina, Dolores;Susser, Ezra
虽然众所周知，精神分裂症与社会阶层有关，但对于这种联系的性质仍存在争议。作者研究了1964年至1976年在耶路撒冷出生的88,829名子女的人口队列中，精神分裂症的发病率与出生时社会阶层的关系。他们根据出生时的父亲职业构建了一个6分制的量表来索引社会阶层，108种职业中的每一种都是根据平均教育程度进行排名的。用COX比例风险法对性别、父母年龄、婚姻年限、出生顺序等因素进行调整。与以色列精神病学登记处的联系发现，在1998年之前，有637人被送往精神病院接受与精神分裂症有关的诊断。精神分裂症的发病风险与出生时的社会阶层无关；然而，处于最低社会阶层的父亲的子女患精神分裂症的风险略有增加(调整后的相对风险=1.4%，95%可信区间=1.11.8，P=0.002)。这些数据表明，与许多其他健康结果相比，随着社会阶层的减少，精神分裂症的增加并不是一个连续的梯度。相反，只有出生在社会阶梯最底层的人患精神分裂症的风险略有增加。
Although it is known that schizophrenia is associated with social class, controversy exists as to the nature of this association. The authors studied the incidence of schizophrenia in relation to social class at birth in a population-based cohort of 88,829 offspring born in Jerusalem in 1964–1976. They constructed a six-point scale to index social class, based on paternal occupation at the time of birth, with each of 108 occupations being ranked by mean education. Cox proportional hazards methods were used in adjusting for sex, parents’ ages, duration of marriage and birth order. Linkage with Israel’s Psychiatric Registry identified 637 people admitted to psychiatric care facilities with schizophrenia-related diagnoses, before 1998. There was no gradient of risk for schizophrenia associated with social class at birth; however, offspring of fathers in the lowest social class showed a modest increase in risk (adjusted Relative Risk = 1.4; 95% Confidence interval = 1.1–1.8, P = 0.002). These data suggest that in contrast to many other health outcomes, there is not a continuous gradient for increasing schizophrenia with decreasing social class of origin. Instead, a modest increase in risk for schizophrenia was observed only for those born at the bottom of the social ladder.
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影响因子：
10.5
作者：
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通讯作者：
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