Peptidomics methods for the identification of peptidase-substrate interactions.
Peptidomics methods for the identification of peptidase-substrate interactions.
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DOI：
10.1016/j.cbpa.2012.10.038
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发表时间：
2013-02
影响因子：
7.8
通讯作者：
Saghatelian, Alan
中科院分区：
文献类型：
--
作者：
Lone, Anna Mari;Kim, Yun-Gon;Saghatelian, Alan
肽酶通过对生物活性肽的调节在生理信号转导中发挥重要作用。了解和控制生物活性肽的调节是巨大的生物医学利益和方法，阐明肽酶和它们的底物之间的相互作用是实现这一目标至关重要。在这里，我们强调最近的肽组学方法在确定内源性底物的肽酶的效用。这些方法揭示了生物活性底物，并有助于表征酶的生化功能。最近，肽组学方法已被应用于解决鉴定负责调节特定生物活性肽的肽酶的挑战性问题。由于肽酶具有很大的生物医学意义，这些方法将开始影响我们鉴定调节重要生物活性肽的新药物靶点的能力。
Peptidases have important roles in controlling physiological signaling through their regulation of bioactive peptides. Understanding and controlling bioactive peptide regulation is of great biomedical interest and approaches that elucidate the interplay between peptidases and their substrates are vital for achieving this goal. Here, we highlight the utility of recent peptidomics approaches in identifying endogenous substrates of peptidases. These approaches reveal bioactive substrates and help characterize the biochemical functions of the enzyme. Most recently, peptidomics approaches have been applied to address the challenging question of identifying the peptidases responsible for regulating specific bioactive peptides. Since peptidases are of great biomedical interest, these approaches will begin to impact our ability to identify new drug targets that regulate important bioactive peptides.
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影响因子：
14.8
作者：
Tagore, Debarati M.;Nolte, Whitney M.;Neveu, John M.;Rangel, Roberto;Guzman-Rojas, Liliana;Pasqualini, Renata;Arap, Wadih;Lane, William S.;Saghatelian, Alan
通讯作者：
Saghatelian, Alan
影响因子：
64.8
作者：
Kosfeld, M;Heinrichs, M;Fehr, E
通讯作者：
Fehr, E
影响因子：
2.3
作者：
Che, FY;Biswas, R;Fricker, LD
通讯作者：
Fricker, LD
影响因子：
3.9
作者：
Tenorio-Laranga, Jofre;Mannisto, Pekka T.;Garcia-Horsman, J. Arturo
通讯作者：
Garcia-Horsman, J. Arturo
影响因子：
3.7
作者：
Martens, Kevin;Derua, Rita;Creemers, John W. M.
通讯作者：
Creemers, John W. M.