Constraints and plasticity in genome and molecular-phenome evolution.

Constraints and plasticity in genome and molecular-phenome evolution.
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DOI:
10.1038/nrg2810
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发表时间:
2010-07
期刊:
Nature reviews. Genetics
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其他
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多种限制因素不同程度地影响着不同生命形式的基因组的不同部分。影响病毒、古生物、细菌和真核生物基因组进化的选择压力明显不同,即使在关系相对密切的动物和细菌谱系之间也是如此;相比之下,影响蛋白质进化的限制似乎更普遍。基因组结构、表达和调控的可塑性和稳健性补充了塑造基因组和物候组进化的制约因素。综上所述,这些发现开始揭示进化过程的复杂网络,必须整合这些网络才能实现进化生物学的新合成。
Multiple constraints variously affect different parts of the genomes of diverse life forms. The selective pressures that shape the evolution of viral, archaeal, bacterial and eukaryotic genomes differ markedly, even among relatively closely related animal and bacterial lineages; by contrast, constraints affecting protein evolution seem to be more universal. The constraints that shape the evolution of genomes and phenomes are complemented by the plasticity and robustness of genome architecture, expression and regulation. Taken together, these findings are starting to reveal complex networks of evolutionary processes that must be integrated to attain a new synthesis of evolutionary biology.
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