Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells.
Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells.
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DOI：
10.1021/jf104901g
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发表时间：
2011-05-11
影响因子：
6.1
通讯作者：
Polans AS
中科院分区：
文献类型：
--
作者：
Kenealey JD;Subramanian L;Van Ginkel PR;Darjatmoko S;Lindstrom MJ;Somoza V;Ghosh SK;Song Z;Hsung RP;Kwon GS;Eliceiri KW;Albert DM;Polans AS
白藜芦醇是一种无毒的多酚，已被证明可以抑制神经母细胞瘤异种移植小鼠模型中的肿瘤生长。然而，白藜芦醇被快速代谢，主要是其葡萄糖醛酸化和硫酸化衍生物。在这项研究中，我们证明，白藜芦醇单独，而不是葡萄糖醛酸化或硫酸化代谢产物，被肿瘤细胞吸收，诱导[Ca2+]i上升，并最终导致肿瘤细胞活力下降。一种新的水溶性白藜芦醇制剂被直接递送到神经母细胞瘤小鼠模型的肿瘤部位。与肿瘤相关的未经修饰的白藜芦醇的量增加了1000倍以上。与肿瘤相关的未修饰的白藜芦醇的增加导致肿瘤消退。随着代谢物相对于未修饰的白藜芦醇的比率下降，保持存活的残留肿瘤细胞的数量也减少。
Resveratrol, a non-toxic polyphenol, has been shown to inhibit tumor growth in a xenograft mouse model of neuroblasoma. However, resveratrol is rapidly metabolized, mainly to its glucuronidated and sulfated derivatives. In this study we demonstrate that resveratrol alone, and not the glucuronidated or sulfated metabolites, is taken up into tumor cells, induces a rise in [Ca2+]i, and ultimately leads to a decrease in tumor cell viability. A new water-soluble resveratrol formulation was delivered directly at the site of the tumor in a neuroblastoma mouse model. The amount of unmodified resveratrol associated with the tumor increased more than 1000-fold. The increase of unmodified resveratrol associated with the tumor resulted in tumor regression. The number of residual tumor cells that remained viable also decreased as the ratio of the metabolites relative to unmodified resveratrol declined.
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影响因子：
5.2
作者：
Wenzel, E;Soldo, T;Somoza, V
通讯作者：
Somoza, V
DOI：
10.1124/jpet.102.033340
发表时间：
2002-07-01
影响因子：
3.5
作者：
Marier, JF;Vachon, P;Ducharme, MP
通讯作者：
Ducharme, MP
影响因子：
5.2
作者：
Gupta SC;Kannappan R;Reuter S;Kim JH;Aggarwal BB
通讯作者：
Aggarwal BB
影响因子：
--
作者：
Grostern, RJ;Bryar, PJ;Albert, DM
通讯作者：
Albert, DM
影响因子：
--
作者：
Sabet, SJ;Darjatmoko, SR;Albert, DM
通讯作者：
Albert, DM