Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation.
Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation.
复制标题
养阴润肠汤改善阿托品/地芬诺酯所致慢传输性便秘小鼠的肠道蠕动
DOI：
10.1155/2017/4249016
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Chen YG
中科院分区：
文献类型：
--
作者：
Jiang F;Zhou JY;Wu J;Tian F;Zhu XX;Zhu CL;Yang BL;Chen YG
This study assessed the efficacy and mechanism of action of Yangyin Runchang decoction (YRD) in the treatment of slow-transit constipation (STC). ICR mice were randomly divided into four groups (n = 10/group) and treated with saline (normal control; NC), atropine/diphenoxylate (model control; MC; 20 mg/kg), or atropine/diphenoxylate plus low-dose YRD (L-YRD; 29.6 g/kg) or high-dose YRD (H-YRD; 59.2 g/kg). Intestinal motility was assessed by evaluating feces and the intestinal transit rate (ITR). The serum level of stem cell factor (SCF) and changes in interstitial cells of Cajal (ICCs) were also evaluated. Additionally, the expression of SCF and c-kit and the intracellular Ca2+ concentration [Ca2+]I were investigated. Fecal volume and ITR were greater in the L-YRD and H-YRD groups than in the MC group. The serum SCF level was lower in the MC group than in the NC group; this effect was ameliorated in the YRD-treated mice. Additionally, YRD-treated mice had more ICCs and elevated expression of c-kit and membrane-bound SCF, and YRD also increased [Ca2+]I in vitro in isolated ICCs. YRD treatment in this STC mouse model was effective, possibly via the restoration of the SCF/c-kit pathway, increase in the ICC count, and enhancement of ICC function by increasing [Ca2+]i.
登录
查看更多内容
DOI：
10.1155/2015/396396
发表时间：
2015
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Wang X;Yin J
通讯作者：
Yin J
长脉冲胃电刺激通过IGF-1信号通路保护糖尿病大鼠Cajal间质细胞
影响因子：
4.3
作者：
Li, Hai;Chen, Yan;Hou, Xiao-Hua
通讯作者：
Hou, Xiao-Hua
影响因子：
29.4
作者：
He, CL;Burgart, L;Farrugia, G
通讯作者：
Farrugia, G
DOI：
10.1111/j.1440-1746.2005.03809.x
发表时间：
2005-08-01
影响因子：
4.1
作者：
Lee, JI;Park, H;Talbot, IC
通讯作者：
Talbot, IC
DOI：
10.1152/ajpgi.00362.2001
发表时间：
2002-05-01
影响因子：
4.5
作者：
Sanders, KM;Ördög, T;Ward, SM
通讯作者：
Ward, SM