Using genetics to enable studies on the prevention of Alzheimer's disease.
Using genetics to enable studies on the prevention of Alzheimer's disease.
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DOI：
10.1038/clpt.2012.222
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发表时间：
2013-02
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
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治愈阿尔茨海默氏病（AD）仍然是一个难以捉摸的目标，可能会被证明是不可能的，由于这种疾病的性质。虽然调节疾病进展是一个有吸引力的目标，并将减轻最严重的疾病阶段的负担，但这一策略不会降低疾病患病率。预防或延迟认知障碍和AD的发作将通过将疾病的发作推迟到更晚的年龄来为个人和社会提供最大的益处。由于发病年龄的高度可变性，不按年龄依赖性疾病风险对参与者进行分层的AD预防研究在操作上具有挑战性-规模大且持续时间长。我们提出了一种复合遗传生物标志物，以分层疾病的风险，有利于在高风险人群的临床研究。此外，我们还讨论了使用吡格列酮延迟高危人群疾病发作的基本原理。
Curing Alzheimer’s disease (AD) remains an elusive goal and may prove to be impossible due to the very nature of the disease. While modulating disease progression is an attractive target and will alleviate the burden of the most severe disease stages, this strategy will not reduce disease prevalence. Preventing or, as will be described, delaying the onset of cognitive impairment and AD will provide the greatest benefit to individuals and society by pushing the onset of disease into later ages. Because of the highly variable age of disease onset, AD prevention studies that do not stratify participants by age-dependent disease risk will be operationally challenging – large in size and of long duration. We present a composite genetic biomarker to stratify disease risk that facilitates clinical studies in high risk people. In addition, we discuss the rationale for the use of pioglitazone to delay disease onset in high risk people.
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影响因子：
11.2
作者：
Gureje, O;Ogunniyi, A;Murrell, JR
通讯作者：
Murrell, JR
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
14
作者：
通讯作者：
--
影响因子：
2.4
作者：
Gold, Michael;Alderton, Claire;Sawchak, Sharon
通讯作者：
Sawchak, Sharon
DOI：
10.1016/j.jalz.2011.11.006
发表时间：
2012-11
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Caselli RJ;Dueck AC;Huentelman MJ;Lutz MW;Saunders AM;Reiman EM;Roses AD
通讯作者：
Roses AD