Phonetically irregular word pronunciation and cortical thickness in the adult brain.
Phonetically irregular word pronunciation and cortical thickness in the adult brain.
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DOI：
10.1016/j.neuroimage.2010.03.028
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发表时间：
2010-07-15
期刊：
影响因子：
5.7
通讯作者：
Thesen, Thomas
中科院分区：
文献类型：
--
作者：
Blackmon, Karen;Barr, William B.;Kuzniecky, Ruben;DuBois, Jonathan;Carlson, Chad;Quinn, Brian T.;Blumberg, Mark;Halgren, Eric;Hagler, Donald J.;Mikhly, Mark;Devinsky, Orrin;McDonald, Carrie R.;Dale, Anders M.;Thesen, Thomas
语音不规则单词（例外单词）的准确发音需要事先了解正字法和音素特征之间的独特关系。这种单词知识是否伴随着与正字法到音素转换相关的区域的结构变化还没有被调查。我们使用高分辨率MRI来确定视觉单词阅读测试（由语音不规则单词组成）的表现，即成人阅读韦氏测试（WTAR），是否与皮质结构的区域变化相关。对60名神经系统完整的右利手个体进行了WTAR，并进行了3 T体积MRI。使用定量，基于表面的图像分析，皮质厚度估计在每个顶点的皮质外套和相关的WTAR分数，同时控制年龄。WTAR评分越高，双侧颞前上级回、双侧角回/颞后上级回和左半球顶内沟的皮质越厚。较高的分数也与左半球后梭状回和中央沟，双侧额下回，右半球舌回和缘上回的皮质较薄有关。这些结果表明，正确发音的能力不规则的单词是与结构的变化，通常激活在功能性神经影像学研究的字阅读，包括相关领域与字形音素转换的皮质区。
Accurate pronunciation of phonetically irregular words (exception words) requires prior exposure to unique relationships between orthographic and phonemic features. Whether such word knowledge is accompanied by structural variation in areas associated with orthographic-to-phonemic transformations has not been investigated. We used high resolution MRI to determine whether performance on a visual word-reading test composed of phonetically irregular words, the Wechsler Test of Adult Reading (WTAR), is associated with regional variations in cortical structure. A sample of 60 right-handed, neurologically intact individuals were administered the WTAR and underwent 3T volumetric MRI. Using quantitative, surface-based image analysis, cortical thickness was estimated at each vertex on the cortical mantle and correlated with WTAR scores while controlling for age. Higher scores on the WTAR were associated with thicker cortex in bilateral anterior superior temporal gyrus, bilateral angular gyrus/posterior superior temporal gyrus, and left hemisphere intraparietal sulcus. Higher scores were also associated with thinner cortex in left hemisphere posterior fusiform gyrus and central sulcus, bilateral inferior frontal gyrus, and right hemisphere lingual gyrus and supramarginal gyrus. These results suggest that the ability to correctly pronounce phonetically irregular words is associated with structural variations in cortical areas that are commonly activated in functional neuroimaging studies of word reading, including areas associated with grapheme-to–phonemic conversion.
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影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
2.5
作者：
COSLETT, HB;MONSUL, N
通讯作者：
MONSUL, N
影响因子：
5.7
作者：
Jobard, G;Crivello, F;Tzourio-Mazoyer, N
通讯作者：
Tzourio-Mazoyer, N
DOI：
10.1016/j.cogbrainres.2005.04.014
发表时间：
2005-09-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Bitan, T;Manor, D;Karni, A
通讯作者：
Karni, A
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI